Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats
Acta cir. bras
;
29(3): 151-157, 03/2014. graf
Article
in English
| LILACS
| ID: lil-703521
ABSTRACT
To analyze the effects of simvastatin (SVT) in the locomotion, anxiety and memory of rats, as a reflection of the administration of a minimum dose capable of stimulating bone regeneration in defects in the calvariae. METHODS:
Surgical procedures were performed in 15 female Wistar rats, 2-month old, to insert the grafting material regenerator (Bone-ceramic(r)) and/or SVT, followed by behavioural and cognitive assessments in the 7th, 30th and 60th days post surgery.RESULTS:
The SVT locally applied with the goal of bone regeneration in defects created in rat calvariae does not interfere with locomotion, anxiety levels and/or memories of rats, except for the first week following surgery, when an anxiolytic effect was observed, as a result of a possible central action.CONCLUSION:
Failure to provoke any response within 30 and 60 days post surgical procedures suggests that SVT may constitute a good choice in stimulating bone regeneration without affecting the long term neural functions.
Full text:
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Index:
LILACS (Americas)
Main subject:
General Surgery
/
Bone Regeneration
/
Simvastatin
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2014
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de Brasilia/BR
/
Universidade de Brasília/BR
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