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Segmental vitiligo after infliximab use for rheumatoid arthritis - A case report
Carvalho, Clarissa Luiza Dalla Bernardina; Ortigosa, Luciena Cegatto Martins.
  • Carvalho, Clarissa Luiza Dalla Bernardina; Universidade do Oeste Paulista. Hospital Regional de Presidente Prudente. Presidente Prudente. BR
  • Ortigosa, Luciena Cegatto Martins; Universidade do Oeste Paulista. Hospital Regional de Presidente Prudente. Presidente Prudente. BR
An. bras. dermatol ; 89(1): 154-156, Jan-Feb/2014. graf
Article in English | LILACS | ID: lil-703547
ABSTRACT
The tumor necrosis factor alpha is a cytokine related to immune and inflammatory processes by acting on different parts of the body. It is secreted by several cell types including macrophages, lymphocytes, monocytes, neutrophils, dendritic cells, among others. Infliximab is a chimeric monoclonal antibody that specifically binds to soluble and transmembrane tumor necrosis factor alpha form blocking its action. In rheumatoid arthritis it is used because the cytokines that cause inflammation in this disease are regulated by tumor necrosis factor alpha and IL-1. We report the case of a 46-year-old patient with rheumatoid arthritis who developed segmental vitiligo after two months using infliximab. The event aims to alert to the existence of this adverse effect that can be induced with the use of this medication.
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Full text: Available Index: LILACS (Americas) Main subject: Arthritis, Rheumatoid / Vitiligo / Antirheumatic Agents / Antibodies, Monoclonal Limits: Female / Humans Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade do Oeste Paulista/BR

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Full text: Available Index: LILACS (Americas) Main subject: Arthritis, Rheumatoid / Vitiligo / Antirheumatic Agents / Antibodies, Monoclonal Limits: Female / Humans Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade do Oeste Paulista/BR