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Single nucleotide polymorphisms in the interferon gamma gene are associated with distinct types of retinochoroidal scar lesions presumably caused by Toxoplasma gondii infection
Peixe, Ricardo Guerra; Boechat, Marcela Santana Bastos; Rangel, Alba Lucinia Peixoto; Rosa, Rhonia Franca Gomes; Petzl-Erler, Maria Luiza; Bahia-Oliveira, Lilian MG.
  • Peixe, Ricardo Guerra; Universidade Estadual do Norte Fluminense. Centro de Biociencias e Biotecnologia. Laboratorio de Biologia do Reconhecer. Campos dos Goytacazes. BR
  • Boechat, Marcela Santana Bastos; Universidade Estadual do Norte Fluminense. Centro de Biociencias e Biotecnologia. Laboratorio de Biologia do Reconhecer. Campos dos Goytacazes. BR
  • Rangel, Alba Lucinia Peixoto; Universidade Estadual do Norte Fluminense. Centro de Biociencias e Biotecnologia. Laboratorio de Biologia do Reconhecer. Campos dos Goytacazes. BR
  • Rosa, Rhonia Franca Gomes; Universidade Estadual do Norte Fluminense. Centro de Biociencias e Biotecnologia. Laboratorio de Biologia do Reconhecer. Campos dos Goytacazes. BR
  • Petzl-Erler, Maria Luiza; Universidade Estadual do Norte Fluminense. Centro de Biociencias e Biotecnologia. Laboratorio de Biologia do Reconhecer. Campos dos Goytacazes. BR
  • Bahia-Oliveira, Lilian MG; Universidade Estadual do Norte Fluminense. Centro de Biociencias e Biotecnologia. Laboratorio de Biologia do Reconhecer. Campos dos Goytacazes. BR
Mem. Inst. Oswaldo Cruz ; 109(1): 99-107, 02/2014. tab, graf
Article in English | LILACS | ID: lil-703638
ABSTRACT
The association of single nucleotide polymorphisms (SNPs) in the interferon (IFN)-γ gene ( IFNG ) with different types of retinal scar lesions presumably caused by toxoplasmosis were investigated in a cross-sectional population-based genetic study. Ten SNPs were investigated and after Bonferroni correction, only the associations between SNPs rs2069718 and rs3181035 with retinal/retinochoroidal scar lesions type A (most severe scar lesions) and C (least severe scar lesions), respectively, remained significant. The associations of two different IFNG SNPs with two different types of retinal lesions attributable to toxoplasmosis support the hypothesis that different inflammatory mechanisms underlie the development of these lesions. The in vitro analysis of IFN-γ secretion by peripheral blood mononuclear cells stimulated with Toxoplasma gondii antigens was also investigated. The association between SNP rs2069718 and type A scar lesions revealed that differential IFN-γ levels are correlated with distinct genotypes. However, no correlation was observed with IFN-γ secretion levels and the SNP rs3181035 , which was significantly associated with type C scar lesions. Our findings strongly suggest that immunogenetic studies of individuals with congenital or postnatally acquired infection are needed to better understand the role of IFN-γ and its polymorphisms in the pathogenesis of ocular toxoplasmosis.
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Full text: Available Index: LILACS (Americas) Main subject: Retinal Diseases / Choroid Diseases / Toxoplasmosis, Ocular / Cicatrix / Interferon-gamma / Polymorphism, Single Nucleotide Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2014 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual do Norte Fluminense/BR

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Full text: Available Index: LILACS (Americas) Main subject: Retinal Diseases / Choroid Diseases / Toxoplasmosis, Ocular / Cicatrix / Interferon-gamma / Polymorphism, Single Nucleotide Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2014 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual do Norte Fluminense/BR