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Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection
Macedo-Silva, Roger Magno; Santos, Carina de Lima Pereira dos; Diniz, Vanessa Alvaro; Carvalho, Jorge Jose de; Guerra, Camila; Corte-Real, Suzana.
  • Macedo-Silva, Roger Magno; Instituto Oswaldo Cruz-Fiocruz. Laboratorio de Biologia Estrutural. Rio de Janeiro. BR
  • Santos, Carina de Lima Pereira dos; Instituto Oswaldo Cruz-Fiocruz. Laboratorio de Biologia Estrutural. Rio de Janeiro. BR
  • Diniz, Vanessa Alvaro; Instituto Oswaldo Cruz-Fiocruz. Laboratorio de Biologia Estrutural. Rio de Janeiro. BR
  • Carvalho, Jorge Jose de; Instituto Oswaldo Cruz-Fiocruz. Laboratorio de Biologia Estrutural. Rio de Janeiro. BR
  • Guerra, Camila; Instituto Oswaldo Cruz-Fiocruz. Laboratorio de Biologia Estrutural. Rio de Janeiro. BR
  • Corte-Real, Suzana; Instituto Oswaldo Cruz-Fiocruz. Laboratorio de Biologia Estrutural. Rio de Janeiro. BR
Mem. Inst. Oswaldo Cruz ; 109(1): 61-69, 02/2014. graf
Article in English | LILACS | ID: lil-703640
ABSTRACT
Fibrocytes are important for understanding the progression of many diseases because they are present in areas where pathogenic lesions are generated. However, the morphology of fibrocytes and their interactions with parasites are poorly understood. In this study, we examined the morphology of peripheral blood fibrocytes and their interactions with Leishmania (L.) amazonensis . Through ultrastructural analysis, we describe the details of fibrocyte morphology and how fibrocytes rapidly internalise Leishmania promastigotes. The parasites differentiated into amastigotes after 2 h in phagolysosomes and the infection was completely resolved after 72 h. Early in the infection, we found increased nitric oxide production and large lysosomes with electron-dense material. These factors may regulate the proliferation and death of the parasites. Because fibrocytes are present at the infection site and are directly involved in developing cutaneous leishmaniasis, they are targets for effective, non-toxic cell-based therapies that control and treat leishmaniasis.
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Full text: Available Index: LILACS (Americas) Main subject: Leukocytes, Mononuclear / Leishmaniasis / Fibroblasts / Leishmania Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Oswaldo Cruz-Fiocruz/BR

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Full text: Available Index: LILACS (Americas) Main subject: Leukocytes, Mononuclear / Leishmaniasis / Fibroblasts / Leishmania Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Oswaldo Cruz-Fiocruz/BR