Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease
Rev. bras. hematol. hemoter
;
36(1): 65-68, Jan-Feb/2014. tab, graf
Article
in English
| LILACS
| ID: lil-703698
ABSTRACT
Long-term survivors of hematopoietic stem cell transplantation are recognized as a risk group for malignization. Malignant oral neoplasms are increasingly being reported in the literature as a consequence of lesions of chronic graft-versus-host disease, and prolonged multidrug treatment to control its manifestations. This report describes a 43-year-old patient who, after allogeneic bone marrow transplantation, developed an oral squamous cell carcinoma secondary to the use of azathioprine, cyclosporine, prednisone, and tacrolimus, associated with multiorgan chronic graft-versus-host disease involving the oral mucosa, skin, eyes, and liver. This report aims to discuss the possible role of immunosuppressant therapy for chronic graft-versus-host disease on the development of oral squamous cell carcinoma, and the relevance of a close oral follow-up of patients to detect dysplastic or malignant alterations at an early stage.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Mouth Neoplasms
/
Leukemia, Myeloid
/
Bone Marrow Transplantation
/
Immunosuppression Therapy
/
Graft vs Host Disease
Limits:
Humans
Language:
English
Journal:
Rev. bras. hematol. hemoter
Journal subject:
Hematology
Year:
2014
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Paraná/BR
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