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Cáncer de mama en mujeres adultas mayores, características clínicas e histopatológicas y resultados del tratamiento con intención curativa / Characteristics and results of breast cancer in elderly females treated with curative inten
Sánchez R, Cesar; Bakal I, Federico; Camus A, Mauricio; Besa de C, Pelayo.
  • Sánchez R, Cesar; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Hematología-Oncología. CL
  • Bakal I, Federico; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Hematología-Oncología. CL
  • Camus A, Mauricio; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Hematología-Oncología. CL
  • Besa de C, Pelayo; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Hematología-Oncología. CL
Rev. méd. Chile ; 141(12): 1534-1540, dic. 2013. graf, tab
Article in Spanish | LILACS | ID: lil-705572
ABSTRACT

Background:

Aging is the main risk factor to acquire breast cancer (BC). Nevertheless BC in elderly patients is sub-represented in clinical trials.

Aim:

To describe the clinical characteristics and long term treatment results of localized BC in older women. Material and

Methods:

Review of medical records of 65 women aged 70 to 88 years, with localized BC, treated with surgery, postoperative radiotherapy or systemic therapy at a Clinical Hospital in Chile.

Results:

The presence of symptoms or abnormal findings on physical examination were the main reasons for consulting in 65% of cases. Compared with tumors detected on physical examination, those detected using screening mammogram were smaller and were in stage 1 with a higher frequency (18 and 59% respectively, p < 0.01). The pathological type was luminal in 80% of cases. Overall survival was better for luminal pathological type. All patients completed radiotherapy without interruptions developing minor acute toxicity. The most common co-morbidity was high blood pressure occurring in 46% of patients. Thirteen percent of patients had three or more co-morbidities. After a median follow up of 7 years, 23 (35%) patients had died and the cause of death was BC in 43% of cases. Two patients died of lung cancer. No patient had a local breast relapse.

Conclusions:

Screening mammogram in older women detected smaller tumors and it was associated with a better survival. BC is the ultimate cause of death in approximately half of cases.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / Carcinoma, Ductal, Breast Type of study: Observational study / Prognostic study / Risk factors Limits: Aged / Aged80 / Female / Humans Country/Region as subject: South America / Chile Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2013 Type: Article Affiliation country: Chile Institution/Affiliation country: Pontificia Universidad Católica de Chile/CL

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Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / Carcinoma, Ductal, Breast Type of study: Observational study / Prognostic study / Risk factors Limits: Aged / Aged80 / Female / Humans Country/Region as subject: South America / Chile Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2013 Type: Article Affiliation country: Chile Institution/Affiliation country: Pontificia Universidad Católica de Chile/CL