Bases epigenéticas del cáncer gástrico: oportunidades para la búsqueda de nuevos biomarcadores / Epigenetics in the pathogenesis and early detection of gastric cancer
Rev. méd. Chile
;
141(12): 1570-1577, dic. 2013. ilus, graf
Article
in Spanish
| LILACS
| ID: lil-705577
ABSTRACT
Gastric cancer is the first cause of death for cancer in Chile. The recently identified genetic alterations in these tumors have not yielded new biomarkers for the disease. Epigenetics or the study of reversible genomic changes that do not affect protein codifying DNA sequences but cause phenotypic disturbances, is identifying new cancer biomarkers. Specifically, the loss of expression caused by the covalent link of a methyl group to carbon 5 of cytosine (DNA hypermethylation) is extensively evaluated. Performing an epigenetic evaluation of 24 genes, we have identified eight genes associated to the aggressive signet ring cell type gastric cancer, the association between APC hypermethylation and worse prognosis and BRCA1 hypermethylation association with early onset of gastric cancer. The most interesting findings are the hypermethylation of Reprimo gene in plasma as a population biomarker and the tissue over expression of p73 gene (as a consequence of hypomethylation) as a high risk indicator of progression to gastric cancer. All these findings are indicating an important role of epigenetics in the pathogenesis and early detection of gastric cancer.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Stomach Neoplasms
/
Glycoproteins
/
Biomarkers, Tumor
/
Cell Cycle Proteins
/
DNA Methylation
/
Epigenomics
Type of study:
Diagnostic study
/
Etiology study
/
Prognostic study
/
Screening study
Limits:
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2013
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Centro UC investigación en oncología (GTO)/CL
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