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Premalignant and malignant lesions in endometrial polyps in patients undergoing hysteroscopic polypectomy / Lesões precursoras e câncer em pólipos do endométrio de pacientes submetidas à polipectomia histeroscópica / Lesões precursoras e câncer em pólipos do endométrio de pacientes submetidas à polipectomia histeroscópica
Lenci, Marco Antonio; Nascimento, Vanessa Alessandra Lui do; Grandini, Ana Beatriz; Fahmy, Walid Makin; Depes, Daniella de Batista; Baracat, Fausto Farah; Lopes, Reginaldo Guedes Coelho.
  • Lenci, Marco Antonio; Hospital Israelita Albert Einstein. São Paulo. BR
  • Nascimento, Vanessa Alessandra Lui do; Hospital Israelita Albert Einstein. São Paulo. BR
  • Grandini, Ana Beatriz; Hospital Israelita Albert Einstein. São Paulo. BR
  • Fahmy, Walid Makin; Hospital Israelita Albert Einstein. São Paulo. BR
  • Depes, Daniella de Batista; Hospital Israelita Albert Einstein. São Paulo. BR
  • Baracat, Fausto Farah; Hospital Israelita Albert Einstein. São Paulo. BR
  • Lopes, Reginaldo Guedes Coelho; Hospital Israelita Albert Einstein. São Paulo. BR
Einstein (Säo Paulo) ; 12(1): 16-21, Jan-Mar/2014. tab
Article in English | LILACS | ID: lil-705793
ABSTRACT

Objective:

To evaluate the incidence of premalignant lesions and cancer in endometrial polyps, in patients undergoing hysteroscopic polypectomy.

Methods:

The results of 1,020 pathological examinations of patients submitted to hysteroscopic polypectomy were analyzed, as well as their diagnostic and surgical hysteroscopy findings. As to their menstrual status, 295 (28.9%) patients were in menacme. Of the total, 193 (65.4%) presented abnormal uterine bleeding, and 102 (34.6%) were asymptomatic with altered endometrial echo on transvaginal ultrasound. Out of 725 (71.1%) postmenopausal patients, 171 (23.6%) were symptomatic (abnormal uterine bleeding), and 554 (76.4%) were asymptomatic with endometrial echo >5.0mm.

Results:

Twenty-one (2.0%) patients presented premalignant lesions in the polyps, 13 had simple glandular hyperplasia, of which 5 had no atypia, and eight presented atypia. Eight polyps presented focal area of complex hyperplasia 4 with atypia and 4 without lesions. Cancer was diagnosed in 5 (0.5%) polyps. Of the 21 polyps that harbored premalignant lesions, 12 were interpreted as benign in diagnostic and surgical hysteroscopy. Of the polyps with cancer, 4 were also histeroscopically interpreted as normal.

Conclusion:

Symptomatic polyps in menacme and in all postmenopausal women should be resected and submitted to histopathological examination, since they may have a benign aspect, even when harboring areas of cellular atypia or cancer. .
RESUMO

Objetivo:

Avaliar a incidência de lesões precursoras e câncer em pólipos do endométrio de pacientes submetidas à polipectomia histeroscópica.

Métodos:

Análise dos resultados de 1.020 exames anatomopatológicos de pacientes submetidas, em hospital público, à polipectomia histeroscópica, e achados em suas histeroscopias diagnóstica e cirúrgica. Em termos de estado menstrual, 295 (28,9%) pacientes encontravam-se na menacme. Do total, 193 (65,4%) apresentavam sangramento uterino anormal e 102 (34,6%) eram assintomáticas, com alteração da medida do eco endometrial à ultrassonografia transvaginal. Das 725 (71,1%) pacientes na pós-menopausa, 171 (23,6%) eram sintomáticas (sangramento uterino anormal) e 554 (76,4%) assintomáticas, com eco endometrial >5,0mm.

Resultados:

Vinte e uma (2,0%) pacientes apresentaram lesões precursoras nos pólipos, 13 com hiperplasia glandular simples, das quais 5 sem atipias e 8 com atipias. Oito pólipos apresentavam área focal de hiperplasia complexa, quatro com atipias e quatro sem lesões. Câncer foi diagnosticado em cinco (0,5%) pólipos. Dos 21 pólipos que abrigavam lesões precursoras, 12 foram interpretados como benignos nas histeroscopias diagnóstica e cirúrgica. Quatro dos pólipos com câncer também foram interpretados histeroscopicamente como normais.

Conclusão:

Os pólipos sintomáticos na menacme, bem como todos na pós-menopausa, devem ser ressecados para realização de exame anatomopatológico, por poderem apresentar aspecto benigno, mesmo quando abrigam áreas de atipia celular ou câncer. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Polyps / Precancerous Conditions / Hysteroscopy / Endometrial Neoplasms Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans Country/Region as subject: South America / Brazil Language: English Journal: Einstein (Säo Paulo) Journal subject: Medicine Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Israelita Albert Einstein/BR

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Full text: Available Index: LILACS (Americas) Main subject: Polyps / Precancerous Conditions / Hysteroscopy / Endometrial Neoplasms Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans Country/Region as subject: South America / Brazil Language: English Journal: Einstein (Säo Paulo) Journal subject: Medicine Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Israelita Albert Einstein/BR