Circulating tumor cells: basic concepts and some clinical applications
Appl. cancer res
;
32(4): 142-152, 2012. tab
Article
in English
| LILACS, Inca
| ID: lil-706012
ABSTRACT
The spread of cancer requires the presence of circulating tumor cells (CTCs), which are rare cells surrounded by billions of normal hematopoietic cells in the bloodstream. It is believed thatCTCs tend to metastasize to certain organs, thus, their presence may determine invasive tumor behavior. Generally, these cells are undetectable by conventional histopathological analysisand imaging exams with high resolution. Therefore, more sensitive immunohistochemical and molecular assays have been developed that have allowed the specific detection of metastatic tumor cells in regional lymph nodes, peripheral blood and bone marrow. This article reviews theliterature regarding CTCs and tumors of the breast, colorectal, pancreas and lung as it pertains to forms of detection and clinicopathological correlations, in addition to future outlooks
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Immunohistochemistry
/
Review Literature as Topic
/
Neoplastic Cells, Circulating
Limits:
Humans
Language:
English
Journal:
Appl. cancer res
Journal subject:
Neoplasms
Year:
2012
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital A.C Camargo/BR
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