Hight chlorpromazine doses and liver function
Braz. j. med. biol. res
;
22(3): 351-3, 1989. tab
Article
in English
| LILACS
| ID: lil-70690
ABSTRACT
The aim of the present study was to evaluate the in vivo effect of high chlorpromazine (CPZ) doses on hepatocellular function. Thirty male Wistar rats weighing 200 to 250 g were divided into two groups control (C, N = 17), injected ip with saline, and CPZ (N = 13), injected ip with high chlorpromazine doses (initial dose of 30 mg/Kg body weight followed by daily doses of 10 mg/Kg for 7 days). No significant differences in serum levels of alanine-aminotransferase, alkaline phosphatase and bilirubin or in mitochondrial function (activated and basal respiration and mitochondrial respiration control(activated/basal ratio) were detected between the two groups
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Index:
LILACS (Americas)
Main subject:
Mitochondria, Liver
/
Chlorpromazine
/
Liver
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1989
Type:
Article
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