An experimental model of chronic rhinosinusitis in rabbits without bacterial inoculation
Acta cir. bras
; 29(5): 313-319, 05/2014. tab, graf
Article
in En
| LILACS
| ID: lil-709233
Responsible library:
BR1.1
ABSTRACT
PURPOSE:
Evaluate and compare two different experimental techniques of maxillary sinus ostium occlusion using N-butyl cyanoacrylate in developing chronic histological findings without the inoculation of pathogenic bacteria among rabbits.METHODS:
In a randomized study, sixteen New Zealand rabbits were assigned for occlusion of the right maxillary sinus through a transmaxillary approach or through the roof of the nasal cavity. The contralateral sinus served as a control. After 12 weeks, the animals were sacrificed for blinded histopathological analysis of the maxillary sinus mucosa.RESULTS:
Histopathological changes consistent with CRS were found in eight (100%) of the maxillary sinuses approached transmaxillary and three of those through the roof of the nasal cavity (37.5%), p 0.008 and 0.250, respectively, comparing with the control side. Chronic mucosal changes were significantly better induced using the transmaxillary approach (p 0.026).CONCLUSION:
It is possible to induce a model of chronic sinusitis among rabbits with transmaxillary sinus occlusion without bacterial inoculation. This model can be replicated for future cellular studies. .Key words
Full text:
1
Index:
LILACS
Main subject:
Sinusitis
/
Rhinitis
/
Disease Models, Animal
/
Maxillary Sinus
/
Nasal Cavity
Type of study:
Etiology_studies
/
Evaluation_studies
/
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2014
Type:
Article