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Rare renal metastases from differentiated thyroid carcinoma: early clinical detection and treatment based on radioiodine / Metástases renais raras de carcinoma diferenciado da tireoide: detecção clínica precoce e tratamento com radioiodoterapia
Qiu, Zhong-Ling; Xue, Yan-Li; Luo, Quan-Yong.
  • Qiu, Zhong-Ling; Shanghai Jiao Tong University. Department of Nuclear Medicine. Shanghai Sixth People?s Hospital. Shanghai. CN
  • Xue, Yan-Li; Shanghai Jiao Tong University. Department of Nuclear Medicine. Shanghai Sixth People?s Hospital. Shanghai. CN
  • Luo, Quan-Yong; Shanghai Jiao Tong University. Department of Nuclear Medicine. Shanghai Sixth People?s Hospital. Shanghai. CN
Arq. bras. endocrinol. metab ; 58(3): 260-269, abr. 2014. tab, graf
Article in English | LILACS | ID: lil-709343
ABSTRACT

Objective:

The aim of this study was to explore the clinical characteristics of renal metastatic cancer, the methods for its detection by radioiodine (131I), and the response to 131I treatment in fourteen patients with renal metastases from differentiated thyroid carcinoma (DTC).Subjects and

methods:

DTC patients (n = 2,955) that received treatment with 131I were retrospectively analyzed. Scans (131I-WBS, 31I-SPECT/CT and/or 18F-FDG-PET/CT) were performed after an oral therapeutic dose of 131I. Therapeutic efficacy was evaluated based on changes in Tg and anatomical imaging changes at renal lesions.

Results:

Among these 14 patients, 11 had avidity for 131I, but three patients did not accumulate 131I after 131I treatment. In the 11 131I-positive renal lesions, 10 cases were detected by 131I-SPECT/CT combined with another imaging modality and one case by 131I-WBS combined with ultrasonography (US). In the three 131I-negative renal lesions, two cases were detected by 18F-FDG-PET/CT and one case by computed tomography (CT). In 11 patients with 131I-avid renal metastases, Serum Tg levels in 81.82% (9/11) patients showed a gradual decline, and 18.18% (2/11) of the patients showed a significant elevation. There was no marked difference in serum Tg before the last 131I treatment (Z = 0.157; p = 0.875). Only one patient presented partial response, eight patients exhibited stable disease, and renal metastases progressed in two patients showing progressive disease. No patients reached complete response.

Conclusion:

131I-SPECT/CT, combined with another imaging modality after 131I-WBS, can contribute to the early detection of renal metastases of DTC. 131I therapy is a feasible and effective treatment for most DTC renal metastases with avidity for 131I. Arq Bras Endocrinol Metab. 2014;58(3)260-9.
RESUMO

Objetivo:

O objetivo deste estudo foi analisar as características clínicas de metástases renais, os métodos para sua detecção por radioiodo (131I) e a resposta ao tratamento com 131I em 14 pacientes com metástases renais de carcinoma diferenciado da tireoide (DTC).Sujeitos e métodos Pacientes com DTC (n = 2.955) que receberam tratamento com 131I foram analisados retrospectivamente. 131I-PCI, 31I-SPECT/CT e/ou 18F-FDG-PET/CT foram feitos após uma dose terapêutica oral de 131I. A eficácia terapêutica foi baseada nas alterações da Tg e nas imagens anatômicas das lesões renais.

Resultados:

Dos 14 pacientes, 11 apresentaram lesões ávidas por 131I, mas três pacientes não acumularam 131I depois do tratamento com 131I. Nas 11 lesões renais positivas para 131I, 10 casos foram detectados por 131I-SPECT/CT combinado com outra modalidade de exame de imagem e um caso por 131I-WBS combinado com US. Nas três lesões renais negativas para 131I, dois casos foram detectados por 18F-FDG-PET/CT e um caso por tomografia computadorizada (TC). Em 11 pacientes com metástases renais ávidas por 131I, os níveis séricos de Tg em 81,82% (9/11) dos pacientes mostraram um declínio gradual e 18,18% (2/11) apresentaram uma elevação significativa. Não houve diferenças marcadas na Tg sérica antes do último tratamento com 131I (Z = 0,157; p = 0,875). Apenas um paciente apresentou resposta parcial, oito pacientes apresentaram doença estável e as metástases renais progrediram em dois pacientes que apresentaram doença progressiva. Nenhum dos pacientes apresentou resposta completa.

Conclusão:

131I-SPECT/CT, combinada com outra modalidade de diagnóstico por imagem após 131I-PCI, pode contribuir para a detecção precoce de metástases renais de DTC. O tratamento ...
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Thyroid Neoplasms / Carcinoma / Rare Diseases / Early Detection of Cancer / Iodine Radioisotopes / Kidney Neoplasms Type of study: Diagnostic study / Observational study / Screening study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Arq. bras. endocrinol. metab Journal subject: Endocrinology / Metabolism Year: 2014 Type: Article Affiliation country: China Institution/Affiliation country: Shanghai Jiao Tong University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Thyroid Neoplasms / Carcinoma / Rare Diseases / Early Detection of Cancer / Iodine Radioisotopes / Kidney Neoplasms Type of study: Diagnostic study / Observational study / Screening study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Arq. bras. endocrinol. metab Journal subject: Endocrinology / Metabolism Year: 2014 Type: Article Affiliation country: China Institution/Affiliation country: Shanghai Jiao Tong University/CN