Effect of astaxanthin and fish oil on enzymatic antioxidant system and ?-amylase activity of salivary glands from rats
Braz. j. oral sci
;
13(1): 58-63, Jan-Mar/2014. tab
Article
in English
| LILACS
| ID: lil-709503
ABSTRACT
Salivary glands contribute to oral health. It is therefore of interest to study therapies that may favor their function and protection. AIM:
To evaluate the effect of astaxanthin, fish oil and association of them on enzymatic antioxidant system and functional parameters of salivary glands.METHODS:
Healthy rats (n=32) were divided into 4 groups untreated-control, astaxanthin-treated (1 mg/kg body weight- BW), fish oil-treated (10 mg EPA/kg BW and 7 mg DHA/kg BW), and fish oil plus astaxanthin-treated. A prophylactic dose was administered in each group daily by gavage, for 45 days. Superoxide dismutase (SOD), catalase, glutathione peroxidase, reductase, and α-amylase activities were determined in salivary glands and compared by ANOVA and Tukey post-test (p<0.05).RESULTS:
Parotid gland presented increased catalase and glutathione system and unaffected SOD activity after astaxanthin and astaxanthin plus fish oil treatment (p<0.05). Fish oil stimulated only glutathione peroxidase activity of parotid gland (p<0.05). Submandibular gland presented stimulated SOD and catalase, and reduced glutathione reductase activities after fish oil and fish oil plus astaxanthin treatment (p<0.05). SOD and glutathione reductase activities were reduced by astaxanthin treatment in submandibular gland (p<0.05). Parotid gland presented increased α-amylase activity in all groups supplemented and submandibular glands presented no changes (p<0.05).CONCLUSIONS:
Astaxanthin, fish oil and combination of them stimulated the antioxidant system and functional parameter of salivary glands, which could be beneficial to oral health.
Full text:
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Index:
LILACS (Americas)
Main subject:
Salivary Glands
/
Fish Oils
/
Carotenoids
/
Alpha-Amylases
/
Antioxidants
Limits:
Animals
Language:
English
Journal:
Braz. j. oral sci
Journal subject:
Dentistry
Year:
2014
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Cruzeiro do Sul/BR
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