Your browser doesn't support javascript.
loading
Tetracycline: production, waste treatment and environmental impact assessment
Borghi, Alexandre Augusto; Palma, Mauri Sergio Alves.
  • Borghi, Alexandre Augusto; University of São Paulo. School of Pharmaceutical Sciences. Department of Biochemical and Pharmaceutical Technology. São Paulo. BR
  • Palma, Mauri Sergio Alves; University of São Paulo. School of Pharmaceutical Sciences. Department of Biochemical and Pharmaceutical Technology. São Paulo. BR
Braz. j. pharm. sci ; 50(1): 25-40, Jan-Mar/2014. tab, graf
Article in English | LILACS | ID: lil-709538
ABSTRACT
The frequent occurrence of pharmaceuticals in the aquatic environment requires an assessment of their environmental impact and their negative effects in humans. Among the drugs with high harmful potential to the environment are the antibiotics that reach the environment not only, as may be expected, through the effluents from chemical and pharmaceutical industries, but mainly through the sewage and livestock; because around 25 to 75% of the ingested drugs are excreted in unchanged form after the passage through the Gastro-Intestinal Tract. Tetracycline has high world consumption, representing a human consumption of about 23 kg/day in Brazil in 2007. At the moment, researches are being made to develop new tetracycline that incorporate heavy metals (Hg, Cd, Re, Pt, Pd) to their structures in order to increase their bactericidal effect. The conventional wastewater treatment plants are not able to degrade complex organic molecules to reduce their toxicity and improve their biodegradability. For this reason new technologies, i.e., the advanced oxidation processes, are being developed to handle this demand. The objectives of this study are to review the literature on the processes of obtaining tetracycline, presenting its waste treatment methods and evaluation of their environmental impact.
RESUMO
A ocorrência frequente de fármacos no meio aquático exige a avaliação do seu impacto ambiental e seus efeitos negativos em seres humanos. Dentre os fármacos com maior potencial de impacto ambiental estão os antibióticos, que chegam ao meio ambiente através dos efluentes de indústrias químico-farmacêuticas e, principalmente, através de esgotos domésticos e criação de animais, visto que 25% a 75% dos fármacos são excretados em forma inalterada após passagem pelo Trato Gastrointestinal. Parcela significativa do consumo mundial dos antibióticos corresponde à classe das tetraciclinas, representando consumo humano de 23 kg/dia no Brasil, em 2007. Atualmente, há pesquisas de novas tetraciclinas que incorporam metais pesados (Hg, Cd, Re, Pt, Pd) às suas estruturas com o intuito de aumentar suas atividades bactericidas. As estações de tratamento de águas residuais convencionais não são capazes de degradar moléculas orgânicas complexas, diminuir a sua toxicidade e melhorar a sua biodegradabilidade. Por esta razão, as novas tecnologias, como, por exemplo, os processos oxidativos avançados, estão sendo desenvolvidos para lidar com esta demanda. Os objetivos deste trabalho são fazer uma revisão da literatura sobre os processos de obtenção de tetraciclinas, apresentar métodos de tratamento de seus resíduos e avaliar o seu impacto ambiental.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Tetracyclines Limits: Humans Language: English Journal: Braz. j. pharm. sci Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of São Paulo/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Tetracyclines Limits: Humans Language: English Journal: Braz. j. pharm. sci Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of São Paulo/BR