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Evaluation of Prunus domestica gum as a novel tablet binder
Rahim, Haroon; Khan, Mir Azam; Badshah, Amin; Chishti, Kamran Ahmad; Khan, Salimullah; Junaid, Muhammad.
  • Rahim, Haroon; Sarhad University of Science and Information Technology Peshawar. Department of Pharmacy. PK
  • Khan, Mir Azam; Sarhad University of Science and Information Technology Peshawar. Department of Pharmacy. PK
  • Badshah, Amin; Sarhad University of Science and Information Technology Peshawar. Department of Pharmacy. PK
  • Chishti, Kamran Ahmad; Sarhad University of Science and Information Technology Peshawar. Department of Pharmacy. PK
  • Khan, Salimullah; Sarhad University of Science and Information Technology Peshawar. Department of Pharmacy. PK
  • Junaid, Muhammad; Sarhad University of Science and Information Technology Peshawar. Department of Pharmacy. PK
Braz. j. pharm. sci ; 50(1): 195-202, Jan-Mar/2014. tab, graf
Article in English | LILACS | ID: lil-709548
ABSTRACT
To evaluate binding potential of Prunus domestica gum in tablets formulations. Six tablet batches (F-1B to F-6B) were prepared by wet granulation method, containing Avicel pH 101 as diluent, sodium diclofenac as model drug using 10, 15 and 20 mg of Prunus domestica gum as binder and PVP K30 was used as standard binder. Magnesium stearate was used as lubricant. Flow properties of granules like bulk density, tapped density, Carr index, Hausner’s ratio, angle of repose as well as physical parameters of the compressed tablets including hardness, friability, thickness and disintegration time were determined and found to be satisfactory. The FTIR spectroscopic analysis showed that the formulation containing plant gum is compatible with the drug and other excipients used in tablets formulation. Hence the plant gum has role as a potential binder in tablets formulations. The dissolution profile showed that tablets formulations containing Prunus domestica gum 15 mg/200 mg of total weight of tablet as binder showed better results as compared to PVP K30.
RESUMO
Para avaliar a propriedade aglutinante da goma Prunus domestica em formulações de comprimidos, seis lotes (F-1B para F-6B) foram preparados pelo método de granulação úmida, contendo Avicel pH 101 como diluente e diclofenaco de sódio como fármaco modelo, usando 10, 15 e 20 mg de goma de Prunus domestica como agente aglutinante e PVP K30 como aglutinante padrão. O estearato de magnésio foi utilizado como lubrificante. Propriedades de fluxo dos grânulos, como a densidade, índice de Carr, razão de Hausner, ângulo de repouso, bem como parâmetros físicos dos comprimidos, incluindo o tempo de dureza, friabilidade, espessura e desintegração foram determinados e se mostraram satisfatórios. A análise espectroscópica no FTIR mostrou que a formulação contendo goma vegetal é compatível com o fármaco e outros excipientes utilizados na formulação dos comprimidos. Assim, a goma vegetal tem papel potencial como aglutinante em formulações de comprimidos. O perfil de dissolução das formulações que contêm 15 mg/200 mg do peso total do comprimido em goma de Prunus domestica como aglutinante mostrou melhores resultados comparativamente ao PVP K30.
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Full text: Available Index: LILACS (Americas) Main subject: Plant Gums / Prunus domestica Language: English Journal: Braz. j. pharm. sci Year: 2014 Type: Article Affiliation country: Pakistan Institution/Affiliation country: Sarhad University of Science and Information Technology Peshawar/PK

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Full text: Available Index: LILACS (Americas) Main subject: Plant Gums / Prunus domestica Language: English Journal: Braz. j. pharm. sci Year: 2014 Type: Article Affiliation country: Pakistan Institution/Affiliation country: Sarhad University of Science and Information Technology Peshawar/PK