Evaluation of Na+, K+-ATPase activity in the brain of young rats after acute administration of fenproporex
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
36(2): 138-142, may. 13, 2014. graf
Article
in English
| LILACS
| ID: lil-710202
ABSTRACT
Objectives:
Fenproporex is an amphetamine-based anorectic which is rapidly converted into amphetamine in vivo. Na+, K+-ATPase is a membrane-bound enzyme necessary to maintain neuronal excitability. Considering that the effects of fenproporex on brain metabolism are poorly known and that Na+, K+-ATPase is essential for normal brain function, this study sought to evaluate the effect of this drug on Na+, K+-ATPase activity in the hippocampus, hypothalamus, prefrontal cortex, and striatum of young rats.Methods:
Young male Wistar rats received a single injection of fenproporex (6.25, 12.5, or 25 mg/kg intraperitoneally) or polysorbate 80 (control group). Two hours after the last injection, the rats were killed by decapitation and the brain was removed for evaluation of Na+, K+-ATPase activity.Results:
Fenproporex decreased Na+, K+-ATPase activity in the striatum of young rats at doses of 6.25, 12.5, and 25 mg/kg and increased enzyme activity in the hypothalamus at the same doses. Na+, K+-ATPase activity was not affected in the hippocampus or prefrontal cortex.Conclusion:
Fenproporex administration decreased Na+, K+-ATPase activity in the striatum even in low doses. However, in the hypothalamus, Na+, K+-ATPase activity was increased. Changes in this enzyme might be the result of the effects of fenproporex on neuronal excitability. .
Full text:
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Index:
LILACS (Americas)
Main subject:
Brain
/
Sodium-Potassium-Exchanging ATPase
/
Amphetamines
Type of study:
Evaluation studies
Limits:
Animals
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2014
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade do Sul de Santa Catarina/BR
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