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Do differences exist between chronic hepatitis C genotypes 2 and 3?
Melo, Isaura Cunha; Ferraz, Maria Lucia Gomes; Perez, Renata Mello; Emori, Christine Takemi; Uehara, Silvia Naomi de Oliveira; Carvalho-Filho, Roberto José de; Silva, Antonio Eduardo Benedito; Souza e Silva, Ivonete Sandra de.
  • Melo, Isaura Cunha; Universidade Federal de São Paulo. Unidade de Hepatologia. Departamento de Gastroenterologia. São Paulo. BR
  • Ferraz, Maria Lucia Gomes; Universidade Federal de São Paulo. Unidade de Hepatologia. Departamento de Gastroenterologia. São Paulo. BR
  • Perez, Renata Mello; Universidade Federal de São Paulo. Unidade de Hepatologia. Departamento de Gastroenterologia. São Paulo. BR
  • Emori, Christine Takemi; Universidade Federal de São Paulo. Unidade de Hepatologia. Departamento de Gastroenterologia. São Paulo. BR
  • Uehara, Silvia Naomi de Oliveira; Universidade Federal de São Paulo. Unidade de Hepatologia. Departamento de Gastroenterologia. São Paulo. BR
  • Carvalho-Filho, Roberto José de; Universidade Federal de São Paulo. Unidade de Hepatologia. Departamento de Gastroenterologia. São Paulo. BR
  • Silva, Antonio Eduardo Benedito; Universidade Federal de São Paulo. Unidade de Hepatologia. Departamento de Gastroenterologia. São Paulo. BR
  • Souza e Silva, Ivonete Sandra de; Universidade Federal de São Paulo. Unidade de Hepatologia. Departamento de Gastroenterologia. São Paulo. BR
Rev. Soc. Bras. Med. Trop ; 47(2): 143-148, Mar-Apr/2014. tab
Article in English | LILACS | ID: lil-710353
ABSTRACT
Introduction Six genotypes of the hepatitis C virus (HCV) have been identified thus far, and their distribution is well defined. Genotype 1, which is the most prevalent worldwide, is always compared to genotypes 2 and 3, particularly in terms of treatment response. However, little is known about the differences between genotypes 2 and 3 because these genotypes are analyzed together in most studies. Therefore, the aim of this study was to evaluate differences in the clinical, epidemiological, laboratory, and histological parameters between HCV-2 and HCV-3. Methods Patients with chronic hepatitis C infected with genotypes 2 and 3 were studied retrospectively and compared according to clinical, laboratory, and histological aspects. Hepatitis C virus-ribonucleic acid (HCV-RNA) was analyzed quantitatively by TaqMan® real-time PCR, and the HCV genotype was determined by sequencing the 5′-untranslated region. Results A total of 306 patients with chronic HCV-2 (n=50) and HCV-3 (n = 256) were studied. Subtype 2b (n=17/50) and subtype 3a (n=244/256) were the most prevalent among patients infected with HCV-2 and HCV-3, respectively. The mean age was 47 ± 10 years, and there was a predominance of men in the group studied (61%). Comparative analysis between HCV-2 and HCV-3 showed a younger age (p=0.002), less prevalence of arterial hypertension (p=0.03), higher serum albumin levels (p=0.01), more advanced stage of liver fibrosis (p=0.03), and higher frequency of steatosis in patients with HCV-3 (p=0.001). After multivariate regression analysis, all the variables, except serum albumin, remained as variables associated with HCV-3 in the final model. Conclusions Clinical and histological differences exist between HCV-2 and HVC-3, which suggests the need for separate analyses of these genotypes. .
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Full text: Available Index: LILACS (Americas) Main subject: RNA, Viral / Hepacivirus / Hepatitis C, Chronic / Genotype Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Male Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: RNA, Viral / Hepacivirus / Hepatitis C, Chronic / Genotype Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Male Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Paulo/BR