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Puerperal brain cryptococcoma in an HIV-negative woman successfully treated with fluconazole: a case report
Hagan, José Edward; Dias, Jesângeli Sousa; Villasboas-Bisneto, José Caetano; Falcão, Melissa Barreto; Ko, Albert Icksang; Ribeiro, Guilherme Sousa.
  • Hagan, José Edward; Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven. US
  • Dias, Jesângeli Sousa; Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven. US
  • Villasboas-Bisneto, José Caetano; Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven. US
  • Falcão, Melissa Barreto; Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven. US
  • Ko, Albert Icksang; Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven. US
  • Ribeiro, Guilherme Sousa; Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven. US
Rev. Soc. Bras. Med. Trop ; 47(2): 254-256, Mar-Apr/2014. graf
Article in English | LILACS | ID: lil-710359
ABSTRACT
Cryptococcus spp. cerebral abscesses are uncommon in immunocompetent subjects. The recommended induction treatment is the administration of amphotericin B plus flucytosine combined with resection for lesions ≥3cm. In this paper, we describe an HIV-negative woman diagnosed with a large cryptococcoma in the immediate postpartum period. The lesion was not resected, and due to amphotericin B intolerance, she received an extended course of fluconazole monotherapy. There was no disease recurrence during the 4 years of follow-up. The abrupt onset of her symptoms following delivery suggests that she developed a postpartum immune reconstitution syndrome. This case also demonstrates that in specific situations fluconazole monotherapy can be attempted in immunocompetent patients with cryptococcoma.
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Full text: Available Index: LILACS (Americas) Main subject: Puerperal Infection / Fluconazole / Meningitis, Cryptococcal / Antifungal Agents Type of study: Diagnostic study Limits: Adult / Female / Humans Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2014 Type: Article / Project document Affiliation country: United States Institution/Affiliation country: Yale School of Public Health/US

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Full text: Available Index: LILACS (Americas) Main subject: Puerperal Infection / Fluconazole / Meningitis, Cryptococcal / Antifungal Agents Type of study: Diagnostic study Limits: Adult / Female / Humans Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2014 Type: Article / Project document Affiliation country: United States Institution/Affiliation country: Yale School of Public Health/US