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RESISTANCE TO AMOXICILLIN, CLARITHROMYCIN AND CIPROFLOXACIN OF Helicobacter pylori ISOLATED FROM SOUTHERN BRAZIL PATIENTS / Resistência à amoxicilina, claritromicina e ciprofloxacina de Helicobacter pylori isolados de pacientes do Sul do Brasil
Picoli, Simone Ulrich; Mazzoleni, Luiz Edmundo; Fernández, Heriberto; De Bona, Laura Renata; Neuhauss, Erli; Longo, Larisse; Prolla, João Carlos.
  • Picoli, Simone Ulrich; Universidade Feevale. Institute of Health Sciences. Novo Hamburgo. BR
  • Mazzoleni, Luiz Edmundo; Universidade Feevale. Institute of Health Sciences. Novo Hamburgo. BR
  • Fernández, Heriberto; Universidade Feevale. Institute of Health Sciences. Novo Hamburgo. BR
  • De Bona, Laura Renata; Universidade Feevale. Institute of Health Sciences. Novo Hamburgo. BR
  • Neuhauss, Erli; Universidade Feevale. Institute of Health Sciences. Novo Hamburgo. BR
  • Longo, Larisse; Universidade Feevale. Institute of Health Sciences. Novo Hamburgo. BR
  • Prolla, João Carlos; Universidade Feevale. Institute of Health Sciences. Novo Hamburgo. BR
Rev. Inst. Med. Trop. Säo Paulo ; 56(3): 197-200, May-Jun/2014. tab
Article in English | LILACS | ID: lil-710406
ABSTRACT

Introduction:

Helicobacter pylori is a bacteria which infects half the world population and is an important cause of gastric cancer. The eradication therapy is not always effective because resistance to antimicrobials may occur. The aim of this study was to determine the susceptibility profile of H. pylori to amoxicillin, clarithromycin and ciprofloxacin in the population of Southern Brazil. Material and

methods:

Fifty four samples of H. pylori were evaluated. The antibiotics susceptibility was determined according to the guidelines of the British Society for Antimicrobial Chemotherapy and the Comité de l'Antibiogramme de la Société Française de Microbiologie.

Results:

Six (11.1%) H. pylori isolates were resistant to clarithromycin, one (1.9%) to amoxicillin and three (5.5%) to ciprofloxacin. These indices of resistance are considered satisfactory and show that all of these antibiotics can be used in the empirical therapy.

Conclusion:

The antibiotics amoxicillin and clarithromycin are still a good option for first line anti-H. pylori treatment in the population of Southern Brazil.
RESUMO

Introdução:

Helicobacter pylori é uma bactéria que infecta metade da população mundial e é considerada importante causa de câncer gástrico. A terapia de erradicação nem sempre é eficaz, pois pode ocorrer a resistência aos antimicrobianos. Este estudo determinou a sensibilidade de H. pylori frente à amoxicilina, claritromicina e ciprofloxacina na população do Sul do Brasil. Material e

métodos:

Foram avaliadas 54 amostras de H. pylori. A sensibilidade aos antibióticos foi determinada segundo as orientações da British Society for Antimicrobial Chemotherapy e do Comité de l'Antibiogramme de la Société Française de Microbiologie. Resultados e discussão Sete (13%) isolados de H. pylori foram resistentes à claritromicina, um (1,9%) à amoxicilina e três (5,5%) à ciprofloxacina. Estes índices são satisfatórios e demonstram que esses antibióticos podem ser utilizados na terapia empírica.

Conclusão:

Os antibióticos amoxicilina e claritromicina ainda são uma boa opção no tratamento de primeira linha anti-H. pylori na população do Sul do Brasil.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Ciprofloxacin / Helicobacter pylori / Clarithromycin / Drug Resistance, Bacterial / Amoxicillin / Anti-Bacterial Agents Type of study: Practice guideline / Qualitative research Limits: Adult / Aged / Aged80 / Humans Country/Region as subject: South America / Brazil Language: English Journal: Rev. Inst. Med. Trop. Säo Paulo Journal subject: Tropical Medicine Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Feevale/BR

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Full text: Available Index: LILACS (Americas) Main subject: Ciprofloxacin / Helicobacter pylori / Clarithromycin / Drug Resistance, Bacterial / Amoxicillin / Anti-Bacterial Agents Type of study: Practice guideline / Qualitative research Limits: Adult / Aged / Aged80 / Humans Country/Region as subject: South America / Brazil Language: English Journal: Rev. Inst. Med. Trop. Säo Paulo Journal subject: Tropical Medicine Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Feevale/BR