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Selected spices and their combination modulate hypercholesterolemia-induced oxidative stress in experimental rats
Otunola, Gloria A; Oloyede, Oyelola B; Oladiji, Adenike T; Afolayan, Anthony J.
  • Otunola, Gloria A; University of Fort Hare. Department of Botany. Medicinal Plant and Economic Development Research Centre. ZA
  • Oloyede, Oyelola B; University of Fort Hare. Department of Botany. Medicinal Plant and Economic Development Research Centre. ZA
  • Oladiji, Adenike T; University of Fort Hare. Department of Botany. Medicinal Plant and Economic Development Research Centre. ZA
  • Afolayan, Anthony J; University of Fort Hare. Department of Botany. Medicinal Plant and Economic Development Research Centre. ZA
Biol. Res ; 47: 1-6, 2014. graf
Article in English | LILACS | ID: lil-710928
ABSTRACT

BACKGROUND:

Effect of aqueous extracts of Allium sativum (garlic), Zingiber officinale (ginger), Capsicum fructensces (cayenne pepper) and their mixture on oxidative stress in rats fed high Cholesterol/high fat diet was investigated. Rats were randomly distributed into six groups (n = 6) and given different dietary/spice treatments. Group 1 standard rat chow (control), group 2, hypercholesterolemic diet plus water, and groups 3, 4, 5, 6, hypercholesterolemic diet with 0.5 ml 200 mg · kg-1 aqueous extracts of garlic, ginger, cayenne pepper or their mixture respectively daily for 4 weeks.

RESULTS:

Pronounced oxidative stress in the hypercholesterolemic rats evidenced by significant (p < 0.05) increase in MDA levels, and suppression of the antioxidant enzymes system in rat's liver, kidney, heart and brain tissues was observed. Extracts of spices singly or combined administered at 200 mg.kg-1 body weight significantly (p < 0.05) reduced MDA levels and restored activities of antioxidant enzymes.

CONCLUSIONS:

It is concluded that consumption of garlic, ginger, pepper, or their mixture may help to modulate oxidative stress caused by hypercholesterolemia in rats.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Spices / Oxidative Stress / Diet, High-Fat / Hypercholesterolemia / Phytotherapy Type of study: Etiology study Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2014 Type: Article Affiliation country: South Africa Institution/Affiliation country: University of Fort Hare/ZA

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Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Spices / Oxidative Stress / Diet, High-Fat / Hypercholesterolemia / Phytotherapy Type of study: Etiology study Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2014 Type: Article Affiliation country: South Africa Institution/Affiliation country: University of Fort Hare/ZA