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Effects of supplementation with omega-3 on insulin sensitivity and non-esterified free fatty acid (NEFA) in type 2 diabetic patients / Efeito da suplementação com ômega-3 sobre a sensibilidade à insulina e aos ácidos graxos livres não esterificados (AGNE) em pacientes com diabetes tipo 2
Farsi, Payam Farahbakhsh; Djazayery, Abolghassem; Eshraghian, Mohammad Reza; Koohdani, Fariba; Saboor-Yaraghi, Ali Akbar; Derakhshanian, Hoda; Zarei, Mahnaz; Javanbakht, Mohammad Hassan; Djalali, Mahmoud.
  • Farsi, Payam Farahbakhsh; Tehran University of Medical Sciences. School of Nutritional Sciences and Dietetics. Department of Cellular and Molecular Nutrition. Tehran. IR
  • Djazayery, Abolghassem; Tehran University of Medical Sciences. School of Nutritional Sciences and Dietetics. Department of Cellular and Molecular Nutrition. Tehran. IR
  • Eshraghian, Mohammad Reza; Tehran University of Medical Sciences. School of Nutritional Sciences and Dietetics. Department of Cellular and Molecular Nutrition. Tehran. IR
  • Koohdani, Fariba; Tehran University of Medical Sciences. School of Nutritional Sciences and Dietetics. Department of Cellular and Molecular Nutrition. Tehran. IR
  • Saboor-Yaraghi, Ali Akbar; Tehran University of Medical Sciences. School of Nutritional Sciences and Dietetics. Department of Cellular and Molecular Nutrition. Tehran. IR
  • Derakhshanian, Hoda; Tehran University of Medical Sciences. School of Nutritional Sciences and Dietetics. Department of Cellular and Molecular Nutrition. Tehran. IR
  • Zarei, Mahnaz; Tehran University of Medical Sciences. School of Nutritional Sciences and Dietetics. Department of Cellular and Molecular Nutrition. Tehran. IR
  • Javanbakht, Mohammad Hassan; Tehran University of Medical Sciences. School of Nutritional Sciences and Dietetics. Department of Cellular and Molecular Nutrition. Tehran. IR
  • Djalali, Mahmoud; Tehran University of Medical Sciences. School of Nutritional Sciences and Dietetics. Department of Cellular and Molecular Nutrition. Tehran. IR
Arq. bras. endocrinol. metab ; 58(4): 335-340, 06/2014. tab
Article in English | LILACS | ID: lil-711628
ABSTRACT

Objective:

The aim of this study was to determine the role of omega-3 supplementation on NEFA concentration, insulin sensitivity and resistance, and glucose and lipid metabolism in type 2 diabetic patients. Subjects and

methods:

Forty-four type 2 diabetic patients were randomly recruited into two groups. Group A received 4 g/day omega-3 soft gels, and group B received a placebo for 10 wks. Blood samples were collected after 12-h fast. Physical activity records, three-day food records, and anthropometric measurements were obtained from all participants at the beginning and end of the study.

Results:

Omega-3 supplementation caused a significant reduction in NEFA in the intervention group compared with the placebo group (P = 0.009). Additionally, the administration of omega-3 resulted in significantly greater changes (Diff) for the intervention group in various parameters, such as insulin and Quicki indices compared with the placebo group (P < 0.05).

Conclusions:

Omega-3 fatty acid supplementation in type 2 diabetic patients improved insulin sensitivity, probably due to the decrease in NEFA concentrations. Arq Bras Endocrinol Metab. 2014;58(4)335-40 .
RESUMO

Objetivo:

O objetivo deste estudo foi analisar o papel da suplementação com ácidos graxos ômega-3 sobre a concentração de ácidos graxos não esterificados (AGNE), resistência e sensibilidade à insulina e metabolismo de lipídios em pacientes com diabetes melito tipo 2. Sujeitos e

métodos:

Quarenta e quatro pacientes com diabetes tipo 2 foram recrutados aleatoriamente e alocados em um de dois grupos. O Grupo A recebeu 4 g/dia de ômega-3 na forma de cápsulas gelatinosas e o grupo B recebeu placebo durante 10 semanas. Amostras de sangue foram coletadas após 12 horas de jejum. Registros da atividade física, da dieta de três dias e medidas antropométricas foram obtidos de todos os participantes no início e no final do estudo.

Resultados:

A suplementação com ômega-3 causou uma redução significativa na AGNE em comparação com grupo placebo (P = 0,008). Além disso, a administração de ômega-3 resultou em alterações significativamente maiores (Dif) em vários parâmetros, tais como a insulina, HOMA-IR e QUICKI, comparando com placebo (P < 0,05).

Conclusões:

A suplementação com ácidos graxos ômega-3 em pacientes diabéticos tipo 2 melhorou a sensibilidade à insulina, provavelmente devido à diminuição da concentração de AGNE. Arq Bras Endocrinol Metab. 2014;58(4)335-40 .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Insulin Resistance / Dietary Supplements / Fatty Acids, Nonesterified Type of study: Controlled clinical trial / Diagnostic study Limits: Adult / Female / Humans / Male Language: English Journal: Arq. bras. endocrinol. metab Journal subject: Endocrinology / Metabolism Year: 2014 Type: Article / Project document Affiliation country: Iran Institution/Affiliation country: Tehran University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Main subject: Insulin Resistance / Dietary Supplements / Fatty Acids, Nonesterified Type of study: Controlled clinical trial / Diagnostic study Limits: Adult / Female / Humans / Male Language: English Journal: Arq. bras. endocrinol. metab Journal subject: Endocrinology / Metabolism Year: 2014 Type: Article / Project document Affiliation country: Iran Institution/Affiliation country: Tehran University of Medical Sciences/IR