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Moringa oleifera impairs the morphology and functions of the kidney in adult Wistar rats / Moringa oleifera altera la morfología y funciones del riñón en ratas Wistar adultas
Akinlolu, Abdulazeez Adelaja; Ghazali, Olaide Kamal; Ameen, Oloduowo Mubarak; Oyebanji, Seunayo Comfort; Omotoso, Gabriel Olaiya; Enaibe, Bernard Ufuoma.
  • Akinlolu, Abdulazeez Adelaja; University of Ilorin. Department of Anatomy. Kwara State. NG
  • Ghazali, Olaide Kamal; University of Ilorin. Department of Anatomy. Kwara State. NG
  • Ameen, Oloduowo Mubarak; University of Ilorin. Department of Chemistry. Kwara State. NG
  • Oyebanji, Seunayo Comfort; University of Ilorin. Department of Anatomy. Kwara State. NG
  • Omotoso, Gabriel Olaiya; University of Ilorin. Department of Anatomy. Kwara State. NG
  • Enaibe, Bernard Ufuoma; University of Ilorin. Department of Anatomy. Kwara State. NG
Int. j. morphol ; 32(2): 469-474, jun. 2014. ilus
Article in English | LILACS | ID: lil-714295
ABSTRACT
We tested the hypothesis that Moringa oleifera impairs the morphology and functions of the kidney in rats. Twenty-four adult male Wistar rats were employed in the study. Rats of Control Group I received physiological saline while rats of Groups II ­ IV received 250, 500 and 750 mg/kg bodyweight of methanolic extract of Moringa oleifera respectively for twenty one days. No behavioral anomalies were observed in rats of Groups I ­ IV. Rats of Control Group I gained statistically significant increased bodyweight while rats of Groups II ­ IV experienced non-significant decreased bodyweight during experimental procedure. (P0.05). No statistical significant differences (P0.05) were observed in the analyses of the relative weights of kidneys of rats of Groups I ­ IV. Histological examinations showed normal cyto-architecture of the kidneys of rats of Group I while the Capsular spaces of the kidneys of rats of Groups II ­ IV appeared wider than those of Group I. Statistical analyses showed significant higher levels (P0.05) of Alanine and Aspartate Transaminases, and serum urea in rats of Groups II ­ IV in a non- dose-dependent manner when compared to rats of Group I. Our findings are consistent with the stated hypothesis.
RESUMEN
Se puso a prueba la hipótesis que Moringa oleifera altera la morfología y función del riñón en ratas. Fueron utilizadas 24 ratas Wistar macho adultas. El grupo control recibió suero fisiológico mientras que los Grupos II a IV recibieron 250, 500 y 750 mg/kg peso corporal del extracto metanólico de Moringa oleifera respectivamente, durante 21 días. No se observaron anomalías en el comportamiento en ratas de los Grupos I - IV. En las ratas del grupo de control se registró un aumento de peso corporal estadísticamente significativo, mientras que las ratas de los grupos II - IV experimentaron una disminución no significativa de peso corporal durante el procedimiento experimental (P0,05). No se observaron diferencias estadísticamente significativas (P0,05) en el análisis de los pesos relativos en riñones de las ratas de los grupos I - IV. Los exámenes histológicos mostraron citoarquitectura normal de los riñones de las ratas del grupo I, mientras que en ratas de los grupos II ­ IV los espacios capsulares de los riñones aparecían más amplios que los del Grupo I. Los análisis estadísticos mostraron niveles superiores significativos ( P 0,05 ) de la alanina y aspartato aminotransferasa, y de urea en suero en ratas de los Grupos II - IV no dependiente de la dosis, en comparación con las ratas del Grupo I. Estos resultados coinciden con la hipótesis planteada.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Moringa oleifera / Kidney Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2014 Type: Article Affiliation country: Nigeria Institution/Affiliation country: University of Ilorin/NG

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Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Moringa oleifera / Kidney Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2014 Type: Article Affiliation country: Nigeria Institution/Affiliation country: University of Ilorin/NG