The preventive effects of natural adjuvants, G2 and G2F on tracheal responsiveness and serum IL-4 and IFN-? (th1/th2 balance) in sensitized guinea pigs
Clinics
;
69(7): 491-496, 7/2014. graf
Article
in English
| LILACS
| ID: lil-714609
ABSTRACT
OBJECTIVE:
The effects of natural adjuvants on lung inflammation and tracheal responsiveness were examined in sensitized guinea pigs.METHODS:
The responses of guinea pig tracheal chains and the serum levels of interleukin-4 and interferon-gamma were examined in control pigs and three other groups of guinea pigs the sensitized group and two other sensitized groups treated with either adjuvant G2 or adjuvant G2F (n = 7 for each group). Sensitization of the animals was achieved by injection and inhalation of ovalbumin.RESULTS:
The results showed that sensitized animals had increased tracheal responsiveness and increased serum levels of interleukin-4 and interferon-gamma compared to controls (p<0.05 to p<0.001). Treatments with either G2 or G2F prevented the increase in tracheal responsiveness and serum interleukin-4 (p<0.01 to p<0.001). However, the serum levels of interferon-gamma and the interleukin-4-to-interferon-gamma ratio was increased in the treated groups (p<0.001 for all cases).CONCLUSIONS:
These results indicate important preventive effects of two natural adjuvants, particularly G2, on the changes in tracheal responsiveness, serum cytokines and the interleukin-4-to-interferon-gamma ratio (T helper 1/T helper 2 balance) in sensitized guinea pigs. .
Full text:
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Index:
LILACS (Americas)
Main subject:
Trachea
/
Adjuvants, Immunologic
Limits:
Animals
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2014
Type:
Article
Affiliation country:
Iran
Institution/Affiliation country:
Mashhad University of Medical Sciences/IR
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