Mitochondrial genome sequence diversity of Indian Plasmodium falciparum isolates
Mem. Inst. Oswaldo Cruz
;
109(4): 494-498, 03/07/2014. tab, graf
Article
in English
| LILACS
| ID: lil-716297
ABSTRACT
We have analysed the whole mitochondrial (mt) genome sequences (each ~6 kilo nucleotide base pairs in length) of four field isolates of the malaria parasite Plasmodium falciparum collected from different locations in India. Comparative genomic analyses of mt genome sequences revealed three novel India-specific single nucleotide polymorphisms. In general, high mt genome diversity was found in Indian P. falciparum, at a level comparable to African isolates. A population phylogenetic tree placed the presently sequenced Indian P. falciparum with the global isolates, while a previously sequenced Indian isolate was an outlier. Although this preliminary study is limited to a few numbers of isolates, the data have provided fundamental evidence of the mt genome diversity and evolutionary relationships of Indian P. falciparum with that of global isolates.
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Index:
LILACS (Americas)
Main subject:
Plasmodium falciparum
/
Genetic Variation
/
Protozoan Proteins
/
DNA, Protozoan
/
Genome, Mitochondrial
Country/Region as subject:
Africa
/
Asia
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2014
Type:
Article
Affiliation country:
India
Institution/Affiliation country:
National Institute of Malaria Research/IN
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