In vivo assessment of antiretroviral therapy-associated side effects
Mem. Inst. Oswaldo Cruz
;
109(4): 484-487, 03/07/2014. tab, graf
Article
in English
| LILACS
| ID: lil-716314
ABSTRACT
Antiretroviral therapy has been associated with side effects, either from the drug itself or in conjunction with the effects of human immunodeficiency virus infection. Here, we evaluated the side effects of the protease inhibitor (PI) indinavir in hamsters consuming a normal or high-fat diet. Indinavir treatment increased the hamster death rate and resulted in an increase in triglyceride, cholesterol and glucose serum levels and a reduction in anti-oxLDL auto-antibodies. The treatment led to histopathological alterations of the kidney and the heart. These results suggest that hamsters are an interesting model for the study of the side effects of antiretroviral drugs, such as PIs.
Full text:
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Index:
LILACS (Americas)
Main subject:
Dietary Fats
/
HIV Protease Inhibitors
/
Indinavir
Type of study:
Risk factors
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2014
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de São Paulo/BR
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