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One-pot synthesis of graphene-chitosan nanocomposite modified carbon paste electrode for selective determination of dopamine
Liu, Chang; Zhang, Jing; Yifeng, E; Yue, Jingli; Chen, Lianshan; Li, Donghui.
  • Liu, Chang; Liaoning Medical University. College of Pharmacy. Jinzhou. CN
  • Zhang, Jing; Liaoning Medical University. College of Pharmacy. Jinzhou. CN
  • Yifeng, E; Liaoning Medical University. College of Pharmacy. Jinzhou. CN
  • Yue, Jingli; Liaoning Medical University. College of Pharmacy. Jinzhou. CN
  • Chen, Lianshan; Liaoning Medical University. College of Pharmacy. Jinzhou. CN
  • Li, Donghui; Liaoning Medical University. College of Pharmacy. Jinzhou. CN
Electron. j. biotechnol ; 17(4): 183-188, July 2014. ilus, graf, tab
Article in English | LILACS | ID: lil-719110
ABSTRACT
Background A simple, rapid, low-cost and environmentally friendly method was developed to determine dopamine (DA) in the presence of ascorbic (AA) and uric acid (UA) based on a novel technique to prepare a graphene-chitosan (GR-CS) nanocomposite and modify it on the surface of carbon paste electrode (CPE). For our design, CS acts as a media to disperse and stabilize GR, and then GR plays a key role to selective and sensitive determination of DA. Results Under physiological conditions, the linear range for dopamine was determined from 1 × 10- 4 to 2 × 10- 7 mol/L with a good correlation coefficient of 0.9961 in the presence of 1000-fold interference of AA and UA. The detection limit was estimated to be 9.82 × 10- 8 mol/L (S/N = 3). In order to study the stability and reproducibility, GR/CS/CPE underwent successive measurements in 10 times and then tested once a d for 30 d. The result exhibited 98.25% and 91.62% activities compared with the original peak current after 10-time measurements and 30-d storage. Conclusion The GR/CS/CPE has wide linear concentration range, low detection limit, and good reproducibility and stability, which suggests that our investigations provide a promising alternative for clinic DA determination.
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Full text: Available Index: LILACS (Americas) Main subject: Carbon / Dopamine / Chitosan / Graphite Language: English Journal: Electron. j. biotechnol Journal subject: Biotechnology Year: 2014 Type: Article Affiliation country: China Institution/Affiliation country: Liaoning Medical University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Carbon / Dopamine / Chitosan / Graphite Language: English Journal: Electron. j. biotechnol Journal subject: Biotechnology Year: 2014 Type: Article Affiliation country: China Institution/Affiliation country: Liaoning Medical University/CN