Effect of allopurinol on the kidney function, histology and injury biomarker (NGAL, IL 18) levels in uninephrectomised rats subjected to ischaemia-reperfusion injury
Acta cir. bras
;
29(8): 515-521, 08/2014. tab, graf
Article
in English
| LILACS
| ID: lil-719184
ABSTRACT
PURPOSE:
To investigate whether allopurinol exerts a protective effect on kidneys by measuring new kidney injury biomarkers (NGALp, NGALu, KIM 1 and IL 18) and analysing the renal function and histology in uninephrectomised rats subjected to ischaemia-reperfusion injury.METHODS:
Thirty two Wistar rats were randomly allocated to four groups Sham (S) laparotomy; Control (C) laparotomy and ischaemia-reperfusion in the left kidney; Control Allopurinol (CA) laparotomy and allopurinol at a dose of 100mg·kg 1·d 1; and Allopurinol (A) laparotomy ischaemia-reperfusion in the left kidney and allopurinol at a dose of 100mg·kg 1·d 1. The NGALp, NGALu, KIM 1, IL 18 and creatinine levels and the kidney histology were analysed. The significance level was established as p<0.05.RESULTS:
Creatinine level increased in all the groups, with A ≈ C > S ≈ CA. The NGALp, NGALu and IL 18 levels exhibited similar behaviour in all the groups. KIM 1 was higher in group A than C and showed intermediate values in groups S and CA. Severity of injury in the left kidney was greater in groups C and A compared to S and CA.CONCLUSION:
Allopurinol did not exert protective or damaging effects on the kidneys of rats subjected to ischaemia-reperfusion injury. .
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Acute-Phase Proteins
/
Allopurinol
/
Proto-Oncogene Proteins
/
Lipocalins
/
Ischemia
/
Kidney
/
Antimetabolites
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2014
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Sao Paulo State University/BR
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