Lard and/or canola oil-rich diets induce penile morphological alterations in a rat model
Acta cir. bras
;
29(supl.1): 39-44, 2014. tab, graf
Article
in English
| LILACS
| ID: lil-720397
ABSTRACT
PURPOSE:
To investigate the effect of dietary lipid quantity and/or quality on penis morphology in adult rats.METHODS:
Thirty-eight male Wistar rats were divided into 4 groups normal lipid diet (NL), high-fat diet rich in saturated fatty acids (HF-S), high-fat diet rich in polyunsaturated fatty acids (HF-P), and high-fat diet rich in saturated and polyunsaturated fatty acids (HF-SP). Blood samples were collected and the penises were removed for histomorphometrical and immunohistochemical analysis.RESULTS:
All high-fat diets promoted an increase in the body mass (p<0.0001). The HF-S and HF-SP groups presented hyperglycemia (p=0.0060), hyperinsulinemia (p=0.0030), and hypercholesterolemia (p=0.0020). Concerning the penis, the high-fat diets led to an increase in the collagen fibers (p<0.0001) and smooth muscle cell density area (p=0.0027), and a decline in the sinusoidal space density area (p<0.0001) and corpus cavernosum cell proliferation (p=0.0003).CONCLUSION:
Diets rich in saturated and/or polyunsaturated fatty acids promoted overweight and induced penile changes in rodent models, which may lead to the development of erectile dysfunction. .
Full text:
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Index:
LILACS (Americas)
Main subject:
Penis
/
Fatty Acids, Monounsaturated
/
Dietary Fats
/
Diet, High-Fat
/
Erectile Dysfunction
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2014
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
State University of Rio de Janeiro/BR
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