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Metabolomics in the fight against malaria
Salinas, Jorge L; Kissinger, Jessica C; Jones, Dean P; Galinski, Mary R.
  • Salinas, Jorge L; Emory University. Emory University School of Medicine. Division of Infectious Diseases. Atlanta. US
  • Kissinger, Jessica C; Emory University. Emory University School of Medicine. Division of Infectious Diseases. Atlanta. US
  • Jones, Dean P; Emory University. Emory University School of Medicine. Division of Infectious Diseases. Atlanta. US
  • Galinski, Mary R; Emory University. Emory University School of Medicine. Division of Infectious Diseases. Atlanta. US
Mem. Inst. Oswaldo Cruz ; 109(5): 589-597, 19/08/2014. graf
Article in English | LILACS | ID: lil-720424
ABSTRACT
Metabolomics uses high-resolution mass spectrometry to provide a chemical fingerprint of thousands of metabolites present in cells, tissues or body fluids. Such metabolic phenotyping has been successfully used to study various biologic processes and disease states. High-resolution metabolomics can shed new light on the intricacies of host-parasite interactions in each stage of the Plasmodium life cycle and the downstream ramifications on the host’s metabolism, pathogenesis and disease. Such data can become integrated with other large datasets generated using top-down systems biology approaches and be utilised by computational biologists to develop and enhance models of malaria pathogenesis relevant for identifying new drug targets or intervention strategies. Here, we focus on the promise of metabolomics to complement systems biology approaches in the quest for novel interventions in the fight against malaria. We introduce the Malaria Host-Pathogen Interaction Center (MaHPIC), a new systems biology research coalition. A primary goal of the MaHPIC is to generate systems biology datasets relating to human and non-human primate (NHP) malaria parasites and their hosts making these openly available from an online relational database. Metabolomic data from NHP infections and clinical malaria infections from around the world will comprise a unique global resource.
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Full text: Available Index: LILACS (Americas) Main subject: Plasmodium / Metabolomics / Host-Parasite Interactions / Malaria Limits: Animals / Humans Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2014 Type: Article / Project document Affiliation country: United States Institution/Affiliation country: Emory University/US

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Full text: Available Index: LILACS (Americas) Main subject: Plasmodium / Metabolomics / Host-Parasite Interactions / Malaria Limits: Animals / Humans Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2014 Type: Article / Project document Affiliation country: United States Institution/Affiliation country: Emory University/US