Anopheles gambiae eicosanoids modulate Plasmodium berghei survival from oocyst to salivary gland invasion
Mem. Inst. Oswaldo Cruz
;
109(5): 668-671, 19/08/2014. graf
Article
in English
| LILACS
| ID: lil-720428
ABSTRACT
Eicosanoids affect the immunity of several pathogen/insect models, but their role on the Anopheles gambiae response to Plasmodium is still unknown. Plasmodium berghei-infected mosquitoes were injected with an eicosanoid biosynthesis inhibitor, indomethacin (IN), or a substrate, arachidonic acid (AA), at day 7 or day 12 post-infection (p.i.). Salivary gland invasion was evaluated by sporozoite counts at day 21 p.i. IN promoted infection upon sporozoite release from oocysts, but inhibited infection when sporozoites were still maturing within the oocysts, as observed by a reduction in the number of sporozoites reaching the salivary glands. AA treatment had the opposite effect. We show for the first time that An. gambiae can modulate parasite survival through eicosanoids by exerting an antagonistic or agonistic effect on the parasite, depending on its stage of development.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Plasmodium berghei
/
Salivary Glands
/
Eicosanoids
/
Oocysts
/
Insect Vectors
/
Anopheles
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2014
Type:
Article
/
Project document
Affiliation country:
Portugal
Institution/Affiliation country:
Universidade Nova de Lisboa/PT
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