Emerging Plasmodium vivax resistance to chloroquine in South America: an overview
Mem. Inst. Oswaldo Cruz
;
109(5): 534-539, 19/08/2014. graf
Article
in English
| LILACS
| ID: lil-720432
ABSTRACT
The global emergence of Plasmodium vivax strains resistant to chloroquine (CQ) since the late 1980s is complicating the current international efforts for malaria control and elimination. Furthermore, CQ-resistant vivax malaria has already reached an alarming prevalence in Indonesia, East Timor and Papua New Guinea. More recently, in vivo studies have documented CQ-resistant P. vivax infections in Guyana, Peru and Brazil. Here, we summarise the available data on CQ resistance across P. vivax-endemic areas of Latin America by combining published in vivo and in vitro studies. We also review the current knowledge regarding the molecular mechanisms of CQ resistance in P. vivax and the prospects for developing and standardising reliable molecular markers of drug resistance. Finally, we discuss how the Worldwide Antimalarial Resistance Network, an international collaborative effort involving malaria experts from all continents, might contribute to the current regional efforts to map CQ-resistant vivax malaria in South America.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Plasmodium vivax
/
Drug Resistance
/
Chloroquine
/
Malaria, Vivax
/
Antimalarials
Type of study:
Risk factors
Limits:
Humans
Country/Region as subject:
South America
/
Bolivia
/
Brazil
/
English Caribbean
/
Colombia
/
Guyana
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2014
Type:
Article
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