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Osteonecrosis severa de los maxilares asociada al uso de bifosfonatos / Severe osteonecrosis of the jaws in a compromised patient subjected to bisphosphonate therapy
Dreyer de Menezes, Juliana; de Mello Rahde, Nicole; Gonçalves Salum, Fernanda; Figueiredo, Maria Antonia; Cherubini, Karen.
  • Dreyer de Menezes, Juliana; Pontifical Catholic University of Rio Grande do Sul. Porto Alegre, RS. BR
  • de Mello Rahde, Nicole; Pontifical Catholic University of Rio Grande do Sul. Porto Alegre, RS. BR
  • Gonçalves Salum, Fernanda; Pontifical Catholic University of Rio Grande do Sul. Porto Alegre, RS. BR
  • Figueiredo, Maria Antonia; Pontifical Catholic University of Rio Grande do Sul. Porto Alegre, RS. BR
  • Cherubini, Karen; Pontifical Catholic University of Rio Grande do Sul. Porto Alegre, RS. BR
Rev. cuba. estomatol ; 51(1): 107-112, ene.-mar. 2014.
Article in English | LILACS, CUMED | ID: lil-721275
ABSTRACT
Bisphosphonate-related osteonecrosis of the jaws is characterized by alveolar bone exposure, especially after mucosal trauma or after surgical procedures, in patients who have previously received or who are currently receiving bisphosphonates without a history of radiation therapy in the maxillofacial region. The condition is refractory to treatment, and attempts at debridement are not completely effective in eradicating the necrotic bone. We report here a case of a severe osteonecrosis of the jaws in a 77-year-old male patient, who had been subjected to chemotherapy and treatment with zoledronic acid and corticosteroid. The patient also had comorbidities such as diabetes and periodontal disease, which might have contributed to the lesion development. Bisphosphonate-related osteonecrosis of the jaws has become a reality in dental clinical practice. Although palliative treatment aiming at controlling pain, infection and injury progression is indicated, the therapeutic strategy is still challenging. So far, the best approach available is prevention, based on oral care before, during, and after bisphosphonate therapy(AU)
RESUMEN
La osteonecrosis de los maxilares asociada al uso de bifosfonatos se traduce en la aparición de hueso alveolar expuesto y necrótico, especialmente después de un trauma de la mucosa o después de procedimientos quirúrgicos, en pacientes que han recibido previamente o que están recibiendo bifosfonatos pero sin historia de radioterapia a región máxilofacial. La afección es refractaria al tratamiento, y los intentos de desbridamiento no son totalmente eficaces en la erradicación del hueso necrótico. Se presenta aquí un caso de una grave osteonecrosis de los maxilares en un paciente masculino de 77 años de edad, que había sido sometido a quimioterapia y tratamiento con ácido zoledrónico y corticosteroides. El paciente también tenía comorbilidades como diabetes y enfermedad periodontal, que pueden haber contribuido al desarrollo de la lesión. El creciente número de casos de esta enfermedad en la literatura ha llamado la atención. Dado que el enfoque terapéutico sigue siendo difícil, la prevención es la mejor estrategia disponible(AU)
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Review Literature as Topic / Maxillary Diseases / Bisphosphonate-Associated Osteonecrosis of the Jaw Limits: Aged / Humans / Male Language: English Journal: Rev. cuba. estomatol Journal subject: Dentistry Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Pontifical Catholic University of Rio Grande do Sul/BR

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Full text: Available Index: LILACS (Americas) Main subject: Review Literature as Topic / Maxillary Diseases / Bisphosphonate-Associated Osteonecrosis of the Jaw Limits: Aged / Humans / Male Language: English Journal: Rev. cuba. estomatol Journal subject: Dentistry Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Pontifical Catholic University of Rio Grande do Sul/BR