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Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats
Ebertz, Claudia Emanuelli; Bonfleur, Maria Lúcia; Bertasso, Iala Milene; Mendes, Mariana Carla; Lubaczeuski, Camila; Araujo, Allan Cezar de Freitas; Paes, Antônio Marcus; Amorim, Elaine Manoela Porto de; Balbo, Sandra Lucinei.
  • Ebertz, Claudia Emanuelli; State University of Western Parana. Cascavel. BR
  • Bonfleur, Maria Lúcia; State University of Western Parana. Cascavel. BR
  • Bertasso, Iala Milene; State University of Western Parana. Cascavel. BR
  • Mendes, Mariana Carla; State University of Western Parana. Cascavel. BR
  • Lubaczeuski, Camila; State University of Western Parana. Cascavel. BR
  • Araujo, Allan Cezar de Freitas; State University of Western Parana. Cascavel. BR
  • Paes, Antônio Marcus; State University of Western Parana. Cascavel. BR
  • Amorim, Elaine Manoela Porto de; State University of Western Parana. Cascavel. BR
  • Balbo, Sandra Lucinei; State University of Western Parana. Cascavel. BR
Acta cir. bras ; 29(9): 609-614, 09/2014. tab, graf
Article in English | LILACS | ID: lil-722128
ABSTRACT

PURPOSE:

To evaluate the effects of duodenal-jejunal bypass (DJB) on serum and hepatic profiles of obese rats fed on a western diet (WD).

METHODS:

Twenty eight male Wistar rats were fed a standard rodent chow diet (CTL group) or WD ad libitum. After 10 weeks, WD rats were submitted to sham (WD SHAM) or duodenal-jejunal bypass (WD DJB). Body weight, fat pad depots, glycemia, insulinemia, HOMA-IR, TyG, lipids profile and hepatic analyses were evaluated two months after surgery.

RESULTS:

The WD SHAM group presented greater obesity, hyperglycemia, hyperinsulinemia, insulin resistance, hypertriglyceridemia and hepatic steatosis than the CTL group. WD DJB rats presented decreased serum glucose and insulin resistance, when compared to WD SHAM animals, without changes in insulinemia. In addition, DJB surgery normalized serum TG and attenuated TG accumulation and steatosis in the liver of the WD DJB group. Hepatic ACC and FAS protein expressions were similar in all groups.

CONCLUSION:

Duodenal-jejunal bypass attenuates hepatic parameters of non-alcoholic fatty liver disease in obese rats fed on a western diet. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Gastric Bypass / Duodenum / Non-alcoholic Fatty Liver Disease / Diet, Western / Jejunum / Obesity Type of study: Evaluation studies / Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: State University of Western Parana/BR

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Full text: Available Index: LILACS (Americas) Main subject: Gastric Bypass / Duodenum / Non-alcoholic Fatty Liver Disease / Diet, Western / Jejunum / Obesity Type of study: Evaluation studies / Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: State University of Western Parana/BR