Oral bacillus Calmette-Guérin vaccine against tuberculosis: why not?
Mem. Inst. Oswaldo Cruz
;
109(6): 838-845, 09/09/2014.
Article
in English
| LILACS
| ID: lil-723988
ABSTRACT
The bacillus Calmette-Guérin (BCG) vaccine is the only licensed vaccine for human use against tuberculosis (TB). Although controversy exists about its efficacy, the BCG vaccine is able to protect newborns and children against disseminated forms of TB, but fails to protect adults against active forms of TB. In the last few years, interest in the mucosal delivery route for the vaccine has been increasing owing to its increased capacity to induce protective immune responses both in the mucosal and the systemic immune compartments. Here, we show the importance of this route of vaccination in newly developed vaccines, especially for vaccines against TB.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Tuberculosis, Pulmonary
/
BCG Vaccine
/
Vaccination
Limits:
Adolescent
/
Adult
/
Child
/
Humans
/
Infant, Newborn
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2014
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto Oswaldo Cruz/BR
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