Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity
Mem. Inst. Oswaldo Cruz
; 109(6): 828-833, 09/09/2014. tab, graf
Article
in En
| LILACS
| ID: lil-723996
Responsible library:
BR1.1
ABSTRACT
This opinion piece presents an approach to standardisation of an important aspect of Chagas disease drug discovery and development selecting Trypanosoma cruzi strains for in vitro screening. We discuss the rationale for strain selection representing T. cruzi diversity and provide recommendations on the preferred parasite stage for drug discovery, T. cruzi discrete typing units to include in the panel of strains and the number of strains/clones for primary screens and lead compounds. We also consider experimental approaches for in vitro drug assays. The Figure illustrates the current Chagas disease drug-discovery and development landscape.
Key words
Full text:
1
Index:
LILACS
Main subject:
Trypanocidal Agents
/
Trypanosoma cruzi
/
Chagas Disease
/
Drug Discovery
Type of study:
Guideline
Language:
En
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
MEDICINA TROPICAL
/
PARASITOLOGIA
Year:
2014
Type:
Article