Immunization of equines with phospholipase A2 protects against the lethal effects of Crotalus durissus terrificus venom
Braz. j. med. biol. res
;
22(4): 509-12, 1989. tab
Article
in English
| LILACS
| ID: lil-72499
RESUMO
Equines (2 horses and 2 donkeyes) immunized with whole Crotalus durissus terrificus venom or its phospholipase A2 component either presented an increased survival time determined 3 days after challenge or were totally resistant to a challenging lethal dose of 200 mg crude venom 270 days after the initial immunization or 90 days after the last booster injection. the resistance was demonstrable on the basis of a good correlation with antibody titers determined by the ELISA method but not with the flocculation and neutralization assays. Since phospholipase A2 is essentially montoxic, it can be used as a substitute for whole venom for the production of commercial antisera ad as an immuniaing agent in prophylalctic progams
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Index:
LILACS (Americas)
Main subject:
Phospholipases
/
Immunization
/
Crotalid Venoms
/
Crotoxin
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1989
Type:
Article
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