Your browser doesn't support javascript.
loading
Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis
Cavalcante, José Roosevelt; Sampaio, João Paulo Aguiar; Maia Filho, João Tarcísio Alves; Vieira, Renato Braga; Eleutério Júnior, José; Lima Júnior, Roberto César Pereira; Ribeiro, Ronaldo Albuquerque; Almeida, Paulo Roberto Carvalho.
  • Cavalcante, José Roosevelt; Federal University of Ceara. School Maternity. Fortaleza. BR
  • Sampaio, João Paulo Aguiar; Federal University of Ceara. School Maternity. Fortaleza. BR
  • Maia Filho, João Tarcísio Alves; Federal University of Ceara. School Maternity. Fortaleza. BR
  • Vieira, Renato Braga; Federal University of Ceara. School Maternity. Fortaleza. BR
  • Eleutério Júnior, José; Federal University of Ceara. School Maternity. Fortaleza. BR
  • Lima Júnior, Roberto César Pereira; Federal University of Ceara. School Maternity. Fortaleza. BR
  • Ribeiro, Ronaldo Albuquerque; Federal University of Ceara. School Maternity. Fortaleza. BR
  • Almeida, Paulo Roberto Carvalho; Federal University of Ceara. School Maternity. Fortaleza. BR
Acta cir. bras ; 29(10): 667-674, 10/2014. tab, graf
Article in English | LILACS | ID: lil-725291
ABSTRACT

PURPOSE:

To investigate E-cadherin immunoexpression during cervical carcinogenesis.

METHODS:

We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL - 52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases of cervicitis.

RESULTS:

The results show very different E-cadherin membrane expression levels when cervicitis (88%), SILs (73%) and SCC (17%) were compared. In SILs, higher E-cadherin loss was seen in less differentiated cells in the basal third of the epithelium. This study suggests that the absence of E-cadherin expression in the membrane is a molecular event that is observed more often in SCC of the uterine cervix than in SILs or cervicitis.

CONCLUSIONS:

E-cadherin is an essential molecule during the process of cervical carcinogenesis and in this context exhibits a different expression pattern according to the epithelial thickness layer. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Carcinoma, Squamous Cell / Cadherins / Uterine Cervicitis / Uterine Cervical Neoplasms / Squamous Intraepithelial Lesions of the Cervix Type of study: Observational study / Prevalence study / Risk factors Limits: Animals / Female / Humans Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Ceara/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Carcinoma, Squamous Cell / Cadherins / Uterine Cervicitis / Uterine Cervical Neoplasms / Squamous Intraepithelial Lesions of the Cervix Type of study: Observational study / Prevalence study / Risk factors Limits: Animals / Female / Humans Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Ceara/BR