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The effect of weight reduction on antioxidant enzymes and their association with dietary intake of vitamins A, C and E / Efeito da redução de peso sobre as enzimas antioxidantes e associação destas com a ingestão de vitaminas A, C e E
Ramezanipour, Masoud; Jalali, Mahmood; Sadrzade-Yeganeh, Haleh; Keshavarz, Seyed Ali; Eshraghian, Mohammad Reza; Bagheri, Minoo; Emami, Sara Seyed.
  • Ramezanipour, Masoud; Tehran University of Medical Sciences. School of Public Health. School of Nutritional Sciences and Dietetic. Department of Cellular and Molecular Nutrition. Tehran. IR
  • Jalali, Mahmood; Tehran University of Medical Sciences. School of Public Health. School of Nutritional Sciences and Dietetic. Department of Cellular and Molecular Nutrition. Tehran. IR
  • Sadrzade-Yeganeh, Haleh; Tehran University of Medical Sciences. School of Public Health. School of Nutritional Sciences and Dietetic. Department of Cellular and Molecular Nutrition. Tehran. IR
  • Keshavarz, Seyed Ali; Tehran University of Medical Sciences. School of Public Health. School of Nutritional Sciences and Dietetic. Department of Cellular and Molecular Nutrition. Tehran. IR
  • Eshraghian, Mohammad Reza; Tehran University of Medical Sciences. School of Public Health. School of Nutritional Sciences and Dietetic. Department of Cellular and Molecular Nutrition. Tehran. IR
  • Bagheri, Minoo; Tehran University of Medical Sciences. School of Public Health. School of Nutritional Sciences and Dietetic. Department of Cellular and Molecular Nutrition. Tehran. IR
  • Emami, Sara Seyed; Tehran University of Medical Sciences. School of Public Health. School of Nutritional Sciences and Dietetic. Department of Cellular and Molecular Nutrition. Tehran. IR
Arq. bras. endocrinol. metab ; 58(7): 744-749, 10/2014. tab
Article in English | LILACS | ID: lil-726257
ABSTRACT
Objective Our goal was to assess the effects of weight loss on antioxidant enzymes of red blood cells and it’s relation with vitamins A, E and C intake in 30 obese women. Subjects and methods General information, anthropometric measurements, 3-day food recall, and fasting blood samples were collected from 30 obese women at the beginning of the study and after 3 months intervention. Weight loss was set at about 10% of their weight before the intervention. Results Glutathione reductase and catalase activities showed a significant increase (P < 0.01) after weight reduction, but no significant changes were seen in the superoxide dismutase and glutathione peroxidase activities. There was a positive linear correlation between daily vitamin C intake with superoxide dismutase enzyme after intervention (P = 0.004, r = 0.507). There was a negative linear correlation between vitamin E intake and glutathione peroxidase activity before intervention (P = 0.005, r = -0.5). A negative correlation was found between daily vitamin A intake and glutathione reductase enzyme before and after intervention (r = -0.385, r = -0.397, P < 0.05) respectively. No significant correlation was observed between vitamins A, C, E amounts and catalase activity. Conclusions Ten percent weight reduction can have a significant role in increasing antioxidant enzymes activities, especially glutathione reductase, and catalase enzymes in obese women. However, it is important to take into consideration a balanced amount of certain nutrients while administering a diet with limited energy. .
RESUMO
Objetivo Nosso objetivo foi avaliar os efeitos da perda de peso sobre as enzimas antioxidantes de eritrócitos, e a relação destas com a ingestão das vitaminas A, E e C. Sujeitos e métodos Foram coletadas informações gerais e medidas antropométricas, registro alimentar de três dias e amostras de sangue em jejum de 30 mulheres obesas no início do estudo e depois de três meses da intervenção. A perda de peso determinada antes da intervenção foi de 10% do peso. Resultados As atividades da glutationa redutase e da catalase mostraram aumento significativo (P < 0,01) depois da perda de peso, mas não houve mudanças significativas nas atividades da superóxido dismutase e da glutationa peroxidase. Foi observada uma correlação linear positiva entre a ingestão diária de vitamina C e a enzima superóxido dismutase após a intervenção (P = 0,004, r = 0,507). Houve uma correlação linear negativa entre a ingestão de vitamina E e a atividade da glutationa peroxidase antes da intervenção (P = 0,005, r = -0,5). Foi observada uma correlação negativa entre a ingestão diária de vitamina A e a enzima glutationa redutase antes e depois da intervenção (r = -0,385, r = -0,397, P < 0,05), respectivamente. Não foram observadas correlações significativas entre as vitaminas A, C, E e os níveis e a atividade da catalase. Conclusões Uma redução de 10% no peso pode ter um papel significativo no aumento da atividade das enzimas antioxidantes, especialmente na glutationa redutase e catalase em mulheres obesas. Entretanto, é importante levar em consideração uma ingestão equilibrada de certos nutrientes ao se recomendar uma dieta com níveis de energia restritos. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Oxidoreductases / Ascorbic Acid / Vitamin A / Vitamin E / Weight Loss / Obesity Type of study: Risk factors Limits: Adult / Female / Humans Language: English Journal: Arq. bras. endocrinol. metab Journal subject: Endocrinology / Metabolism Year: 2014 Type: Article Affiliation country: Iran Institution/Affiliation country: Tehran University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Main subject: Oxidoreductases / Ascorbic Acid / Vitamin A / Vitamin E / Weight Loss / Obesity Type of study: Risk factors Limits: Adult / Female / Humans Language: English Journal: Arq. bras. endocrinol. metab Journal subject: Endocrinology / Metabolism Year: 2014 Type: Article Affiliation country: Iran Institution/Affiliation country: Tehran University of Medical Sciences/IR