Genética de la diabetes mellitus tipo 1 / Genetic of type 1 diabetes mellitus
Rev. chil. endocrinol. diabetes
;
6(1): 15-22, ene. 2013. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-726584
ABSTRACT
Type 1 diabetes (T1D) results from autoimmune-mediated destruction of the pancreatic beta cells, a process that is conditioned by multiple genes and environmental factors. The process that destroys the pancreatic b cells in T1D is mediated by T cells and leads to a complex phenotype influenced by multiple factors. It has been more than 30 years since the publication of the first evidence suggesting the involvement of a specific chromosomal region, HLA, in modulating the risk for T1D. HLA locus has been known for decades to contribute strongly with the attributable to genetic risk. In addition to HLA, many proposed candidate loci have been described that are associated with risk of developing the disease, including the insulin gene (INS), PTPN22,CTLA-4, PD-1, IL2-RA and IFIH1 which together do not contribute more than 15 percent of the risk. This review compiled the data on T1D genes and discusses the major genetic impact of these genetic aspects in T1D etiology.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Genetic Markers
/
Diabetes Mellitus, Type 1
Limits:
Humans
Language:
Spanish
Journal:
Rev. chil. endocrinol. diabetes
Journal subject:
Endocrinology
Year:
2013
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Pontificia Universidad Católica de Chile/CL
/
Universidad de Chile/CL
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