Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction
Braz. j. microbiol
;
45(3): 807-812, July-Sept. 2014. ilus, tab
Article
in English
| LILACS
| ID: lil-727006
ABSTRACT
Bacterial resistance to commonly used antibiotics has been recognized as a significant global health issue. In this study, we carried out the screening of a family of allylic thiocyanates for their action against a diversity of bacteria and fungi with a view to developing new antimicrobial agents. Allylic thiocyanates bearing halogenated aryl groups, which were readily obtained in two steps from the Morita-Baylis-Hillman adducts, showed moderate-to-high activity against selective pathogens, including a methicillin-resistant S. aureus (MRSA) strain. In particular cases, methyl (Z)-3-(2,4-dichlorophenyl)-2-(thiocyanomethyl)-2-propenoate exhibited antimicrobial activity comparable to the reference antibiotic Imipenem.
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Index:
LILACS (Americas)
Main subject:
Thiocyanates
/
Bacteria
/
Allyl Compounds
/
Fungi
/
Anti-Infective Agents
Language:
English
Journal:
Braz. j. microbiol
Journal subject:
Microbiology
Year:
2014
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Santa Catarina/BR
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