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Refractory pemphigus vulgaris treated with rituximab and mycophenolate mofetil
Biot, Stephanie Del Rio Navarrete; Franco, Joanna Pimenta de Araujo; Lima, Ricardo Barbosa; Pereira, Henrique Novo Costa; Marques, Luiz Paulo José; Martins, Carlos José.
  • Biot, Stephanie Del Rio Navarrete; Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Rio de Janeiro. BR
  • Franco, Joanna Pimenta de Araujo; Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Rio de Janeiro. BR
  • Lima, Ricardo Barbosa; Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Rio de Janeiro. BR
  • Pereira, Henrique Novo Costa; Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Rio de Janeiro. BR
  • Marques, Luiz Paulo José; Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Rio de Janeiro. BR
  • Martins, Carlos José; Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Rio de Janeiro. BR
An. bras. dermatol ; 89(6): 980-984, Nov-Dec/2014. tab, graf
Article in English | LILACS | ID: lil-727637
ABSTRACT
The main treatment for pemphigus vulgaris are systemic corticosteroids and immunosuppressive agents, but due to adverse reactions and therapeutic failure, new drugs such as rituximab and mycophenolate mofetil have been used. In this case report are described two cases of severe pemphigus vulgaris refractory to various treatments, with resolution after use of rituximab and mycophenolate mofetil, associated with corticosteroids. A higher-than-usual dose of rituximab was employed, without the occurrence of serious adverse reactions. Mycophenolate mofetil was added as adjunctive therapy due to lack of response to azathioprine.
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Full text: Available Index: LILACS (Americas) Main subject: Pemphigus / Antibodies, Monoclonal, Murine-Derived / Immunologic Factors / Immunosuppressive Agents / Mycophenolic Acid Limits: Female / Humans / Male Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Estado do Rio de Janeiro (UNIRIO)/BR

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Full text: Available Index: LILACS (Americas) Main subject: Pemphigus / Antibodies, Monoclonal, Murine-Derived / Immunologic Factors / Immunosuppressive Agents / Mycophenolic Acid Limits: Female / Humans / Male Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Estado do Rio de Janeiro (UNIRIO)/BR