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Acute stress-induced antinociception is cGMP-dependent but heme oxygenase-independent
Carvalho-Costa, P.G.; Branco, L.G.S.; Leite-Panissi, C.R.A..
  • Carvalho-Costa, P.G.; Universidade de São Paulo. Ciências e Letras de Ribeirão Preto. Faculdade de Filosofia. Programa de Graduação em Psicobiologia. Ribeirão Preto. BR
  • Branco, L.G.S.; Universidade de São Paulo. Ciências e Letras de Ribeirão Preto. Faculdade de Filosofia. Programa de Graduação em Psicobiologia. Ribeirão Preto. BR
  • Leite-Panissi, C.R.A.; Universidade de São Paulo. Ciências e Letras de Ribeirão Preto. Faculdade de Filosofia. Programa de Graduação em Psicobiologia. Ribeirão Preto. BR
Braz. j. med. biol. res ; 47(12): 1057-1061, 12/2014. graf
Article in English | LILACS | ID: lil-727658
ABSTRACT
Endogenous carbon monoxide (CO), which is produced by the enzyme heme oxygenase (HO), participates as a neuromodulator in physiological processes such as thermoregulation and nociception by stimulating the formation of 3′,5′-cyclic guanosine monophosphate (cGMP). In particular, the acute physical restraint-induced fever of rats can be blocked by inhibiting the enzyme HO. A previous study reported that the HO-CO-cGMP pathway plays a key phasic antinociceptive role in modulating noninflammatory acute pain. Thus, this study evaluated the involvement of the HO-CO-cGMP pathway in antinociception induced by acute stress in male Wistar rats (250-300 g; n=8/group) using the analgesia index (AI) in the tail flick test. The results showed that antinociception induced by acute stress was not dependent on the HO-CO-cGMP pathway, as neither treatment with the HO inhibitor ZnDBPG nor heme-lysinate altered the AI. However, antinociception was dependent on cGMP activity because pretreatment with the guanylate cyclase inhibitor 1H-[1,2,4] oxadiazolo [4,3-a] quinoxaline-1-one (ODQ) blocked the increase in the AI induced by acute stress.
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Full text: Available Index: LILACS (Americas) Main subject: Carbon Monoxide / Cyclic GMP / Stress Disorders, Traumatic, Acute / Acute Pain / Nociceptive Pain / Heme Oxygenase (Decyclizing) Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2014 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Carbon Monoxide / Cyclic GMP / Stress Disorders, Traumatic, Acute / Acute Pain / Nociceptive Pain / Heme Oxygenase (Decyclizing) Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2014 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR