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Role of high mobility group box-1 and protection of growth hormone and somatostatin in severe acute pancreatitis
Wang, Y.F.; Wu, M.; Ma, B.J.; Cai, D.A.; Yin, B.B..
  • Wang, Y.F.; Huashan Hospital, Fudan University. Department of Surgery. Shanghai. CN
  • Wu, M.; Huashan Hospital, Fudan University. Department of Surgery. Shanghai. CN
  • Ma, B.J.; Huashan Hospital, Fudan University. Department of Surgery. Shanghai. CN
  • Cai, D.A.; Huashan Hospital, Fudan University. Department of Surgery. Shanghai. CN
  • Yin, B.B.; Huashan Hospital, Fudan University. Department of Surgery. Shanghai. CN
Braz. j. med. biol. res ; 47(12): 1075-1084, 12/2014. tab, graf
Article in English | LILACS | ID: lil-727668
ABSTRACT
In this study, we investigated the potential role of high-mobility group box 1 (HMGB1) in severe acute pancreatitis (SAP) and the effects of growth hormone (G) and somatostatin (S) in SAP rats. The rats were randomly divided into 6 groups of 20 each sham-operated, SAP, SAP+saline, SAP+G, SAP+S and SAP+G+S. Ileum and pancreas tissues of rats in each group were evaluated histologically. HMGB1 mRNA expression was measured by reverse transcription-PCR. Levels of circulating TNF-α, IL-1, IL-6, and endotoxin were also measured. In the SAP group, interstitial congestion and edema, inflammatory cell infiltration, and interstitial hemorrhage occurred in ileum and pancreas tissues. The levels of HMGB1, TNF-α, IL-1, IL-6 and endotoxin were significantly up-regulated in the SAP group compared with those in the sham-operated group, and the 7-day survival rate was 0%. In the SAP+G and SAP+S groups, the inflammatory response of the morphological structures was alleviated, the levels of HMGB1, TNF-α, IL-1, IL-6, and endotoxin were significantly decreased compared with those in the SAP group, and the survival rate was increased. Moreover, in the SAP+G+S group, all histological scores were significantly improved and the survival rate was significantly higher compared with the SAP group. In conclusion, HMGB1 might participate in pancreas and ileum injury in SAP. Growth hormone and somatostatin might play a therapeutic role in the inflammatory response of SAP.
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Full text: Available Index: LILACS (Americas) Main subject: Pancreas / Somatostatin / Growth Hormone / Pancreatitis, Acute Necrotizing / HMGB1 Protein Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2014 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Huashan Hospital, Fudan University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Pancreas / Somatostatin / Growth Hormone / Pancreatitis, Acute Necrotizing / HMGB1 Protein Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2014 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Huashan Hospital, Fudan University/CN