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Morphometrical analysis of the effect of nicotine administration on brain's prefrontal region in male rat / Análisis morfométrico del efecto de la administración de nicotina sobre la región prefrontal del cerebro en rata macho
Jalili, C; Salahshoor, M. R; Khademi, F; Jalili, P; Roshankhah, S. H.
  • Jalili, C; Kermanshah University of Medical Sciences. Fertility and Infertility Research Center. Kermanshah. IR
  • Salahshoor, M. R; Kermanshah University of Medical Sciences. Fertility and Infertility Research Center. Kermanshah. IR
  • Khademi, F; Kermanshah University of Medical Sciences. Kermanshah. IR
  • Jalili, P; Kermanshah University of Medical Sciences. Fertility and Infertility Research Center. Kermanshah. IR
  • Roshankhah, S. H; Kermanshah University of Medical Sciences. Fertility and Infertility Research Center. Kermanshah. IR
Int. j. morphol ; 32(3): 761-766, Sept. 2014. ilus
Article in English | LILACS | ID: lil-728263
ABSTRACT
Nicotine is the most important alkaloid compound in tobacco. One of the major effects of nicotine is stimulation of mesocorticolimbic system. Prefrontal cortex plays a pivotal role in personality and mental state. It is considered the main cause of addiction as it is located in mesocorticolimbic dopamine system. Twenty four male rats were divided into four groups based on nicotine administration dose (0, 0.5, 1 and 1.5 g/kg). After animals were anesthetized, their brains were fixed using transcardiac method. Tissue processing and Golgi staining were performed and the stained tissue sections were analyzed by optic microscope and Motic software. By increasing the dose, nicotine significantly decreased the number of neuronal processes. In the higher dose, nicotine caused a significant decrease and increase in the size of pericarions and dendritic spines, respectively (p<0.05). Nicotine administration can decrease the size of pericarion and number of dendritic spines in the prefrontal cortex.
RESUMEN
La nicotina es el compuesto alcaloide más importante del tabaco. Uno de sus principales efectos es la estimulación del sistema mesocorticolímbico. La corteza prefrontal desempeña un papel fundamental en la personalidad y estado mental. Esta es considerada la principal causa de la adicción, ya que se encuentra en el sistema mesocorticolímbico dopaminérgico. Veinticuatro ratas macho fueron divididas en cuatro grupos basados en la dosis de administración de nicotina (0, 0,5, 1 y 1,5 g/kg). Luego fueron anestesiados y sus cerebros se fijaron mediante perfusión transcardíaca. Se realizó el procesamiento de tejidos y las secciones bajo tinción de Golgi fueron analizadas mediante microscopia óptica y el software Motic. Con el aumento de dosis, la nicotina redujo significativamente el número de procesos neuronales. En la dosis más alta, la nicotina causó una disminución y aumento significativo en el tamaño de pericarion y espinas dendríticas, respectivamente (p<0,05). La administración de nicotina puede disminuir el tamaño del pericarion y el número de espinas dendríticas en la corteza prefrontal.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Prefrontal Cortex / Nicotine Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2014 Type: Article Affiliation country: Iran Institution/Affiliation country: Kermanshah University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Main subject: Prefrontal Cortex / Nicotine Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2014 Type: Article Affiliation country: Iran Institution/Affiliation country: Kermanshah University of Medical Sciences/IR