Impacto clínico de un sistema de farmacovigilancia activa realizado por un farmacéutico en el reporte y subnotificación de reacciones adversas a medicamentos / Assessment of an active pharmacovigilance system carried out by a pharmacist
Rev. méd. Chile
;
142(8): 998-1005, ago. 2014. graf, tab
Article
in Spanish
| LILACS
| ID: lil-728348
ABSTRACT
Background:
Despite the importance of notifying and preventing adverse drug reactions (ADRs), they are under reported and their consequences are not adequately evaluated.Aim:
To assess the impact of a pharmacovigilance system carried out by a pharmacist. Material andMethods:
In an internal medicine service, the spontaneous report of ADRs was compared blindly with an active pharmacovigilance system in which a pharmacist detected, monitored and prevented ADRs.Results:
A total of 1,196 patients was included. Of these 604 were hospitalized in intervened wards, where 50 suspected ADRs in 47 patients were reported. In non-intervened wards, only three ADRs were spontaneously reported. Therefore, the pharmacovigilance system significantly improved the detection and report of ADRs with a risk ratio of 15.4 (95% confidence intervals 4.8-49.1). Sixty six percent of ADRs were classified as severe. Antimicrobials were the main group of medications causing ADRs in 44% of reports. Forty three percent of ADRs were preventable and prolonged hospital stay by a mean of eight days.Conclusions:
An active pharmacovigilance system carried out by pharmacists improves the detection of ADRs and promotes its prevention.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pharmacists
/
Drug-Related Side Effects and Adverse Reactions
/
Pharmacovigilance
Type of study:
Diagnostic study
/
Etiology study
/
Evaluation studies
/
Incidence study
/
Observational study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2014
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Hospital del Salvador/CL
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