Estudio histomorfométrico del núcleo celular del carcinoma papilar de tiroides / Histomorphometric study of the cellular nucleus of the thyroid papillary carcinoma

RESUMEN

Se realizó una evaluación morfométrica del carcinoma papilar tiroideo, con el objetivo de identificar posibles indicadores morfométricos que contribuyan a precisar su diagnóstico histológico. Se estudiaron 32 biopsias diagnosticadas en el Hospital Universitario “Celestino Hernández Robau”, de Santa Clara. Se determinaron las variables morfométricas nucleares: área, perímetro, radio y factor de forma, utilizando el programa de computación COMSDI PLUS versión 1.0. El carcinoma papilar en sus variantes hísticas no clásicas (folicular, oxífila y esclerosante difusa) presentaron valores más elevados del área, perímetro y radio nuclear, mientras que el carcinoma papilar, en su variante clásica, mostró un valor mayor de factor de forma. El estudio de correlación entre las variables estudiadas, en ambas variantes hísticas, no mostró similitud en sus resultados.

ABSTRACT

A morphometric evaluation of thyroid papillary carcinoma was carried out, with the objective of identifying possible morphometric parameters that contribute to precise its histological diagnosis. A number of 32 diagnosed biopsies of the University Hospital “Celestino Hernández Robau”, from Santa Clara were studied. Nuclear morphometric variables were determined, such as, area, perimeter, range and shape factor, by means of COMSDI PLUS version 1.0 computing program. Papillary carcinoma in its non classical histological variants (follicular, oxyphilic and diffuse sclerosing) showed more elevated values in area, perimeter and nuclear range, while, papillary carcinoma, in its classical variant, showed a high value in shape factor. The correlation study between studied variables did not showed similarity in its results in both histological variants.