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Association of lipophilic opioids and hyperbaric bupivacaine in spinal anesthesia for elective cesarean section. Randomized controlled study
Braga, Angélica de Fátima de Assunção; Braga, Franklin Sarmento da Silva; Hirata, Eunice Sizue; Pereira, Rosa Inês Costa; Frias, José Aristeu; Antunes, Isadora Fregonese.
  • Braga, Angélica de Fátima de Assunção; Campinas State University. School of Medicine. Department of Anesthesiology. Campinas. BR
  • Braga, Franklin Sarmento da Silva; Campinas State University. School of Medicine. Department of Anesthesiology. Campinas. BR
  • Hirata, Eunice Sizue; Campinas State University. School of Medicine. Department of Anesthesiology. Campinas. BR
  • Pereira, Rosa Inês Costa; Campinas State University. School of Medicine. Department of Anesthesiology. Campinas. BR
  • Frias, José Aristeu; Campinas State University. School of Medicine. Department of Anesthesiology. Campinas. BR
  • Antunes, Isadora Fregonese; Campinas State University. School of Medicine. Department of Anesthesiology. Campinas. BR
Acta cir. bras ; 29(11): 752-758, 11/2014. tab
Article in English | LILACS | ID: lil-728642
ABSTRACT

PURPOSE:

To evaluate the efficacy and side-effects of fentanyl and sufentanil combined with hyperbaric spinal bupivacaine in elective cesarean section.

METHODS:

A prospective, randomized, double-blind study with 64 term parturients, distributed into 2 groups according to the opioid combined with hyperbaric bupivacaine 0.5% (10mg) GF - fentanyl (25µg) and GS - sufentanil (5.0µg). The latency and maximum sensory block level; degree and duration of motor block; duration and quality of analgesia; maternal-fetal repercussions were evaluated. This was an intention-to-treat analysis with a 5% significance level.

RESULTS:

The latency period, maximum sensory block level, motor block degree and perioperative analgesia were similar in both groups. Motor block and analgesia had a longer duration in the sufentanil group. Maternal adverse effects and neonatal repercussions were similar. The incidence of hypotension was higher in the fentanyl group. In both groups, there was a predominance of patients who were awake and either calm or sleepy.

CONCLUSIONS:

The addition of fentanyl and sufentanil to hyperbaric subarachnoid bupivacaine was shown to be effective for the performance of cesarean section, and safe for the mother and fetus. Analgesia was more prolonged with sufentanil. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Bupivacaine / Cesarean Section / Fentanyl / Sufentanil / Analgesics, Opioid / Anesthesia, Obstetrical / Anesthetics, Local Type of study: Controlled clinical trial / Observational study / Risk factors Limits: Adult / Female / Humans / Pregnancy Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Campinas State University/BR

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Full text: Available Index: LILACS (Americas) Main subject: Bupivacaine / Cesarean Section / Fentanyl / Sufentanil / Analgesics, Opioid / Anesthesia, Obstetrical / Anesthetics, Local Type of study: Controlled clinical trial / Observational study / Risk factors Limits: Adult / Female / Humans / Pregnancy Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Campinas State University/BR