Laparoscopic guided local injection in the X-linked muscular dystrophy mouse (mdx) diaphragm. An advance in experimental therapies for Duchenne Muscular Dystrophy
Acta cir. bras
;
29(11): 715-720, 11/2014. graf
Article
in English
| LILACS
| ID: lil-728648
ABSTRACT
PURPOSE:
To investigate the development of a laparoscopy technique for local injection into the X-linked muscular dystrophy (mdx) diaphragm.METHODS:
It was used 10 mice Balb/C57 and 5 mdx mice and three differents decubitus type were tested the right lateral, supine, and supine decubitus with 20 degrees elevation of the forelimb. Abdominal caudal face and the 10 intercostal space were tested as spot to introduce the needle into the diaphragm.RESULTS:
Supine position with elevation of 20 degrees forelimb and the 10th intercostal space are the beneficial position to apply a local injection.CONCLUSION:
It was proved to be possible to perform the laparoscopy technique in the X-linked muscular dystrophy diaphragm and this requires a specific position and technique during the surgery. .
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Respiratory Insufficiency
/
Diaphragm
/
Laparoscopy
/
Muscular Dystrophy, Duchenne
/
Injections, Intramuscular
/
Muscular Dystrophy, Animal
Type of study:
Etiology study
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2014
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
University of Sao Paulo/BR
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