Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
Mem. Inst. Oswaldo Cruz
;
109(7): 948-951, 11/2014. tab, graf
Article
in English
| LILACS
| ID: lil-728801
ABSTRACT
The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the molecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax isolates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Plasmodium vivax
/
Genetic Variation
/
Drug Resistance
/
Chloroquine
/
DNA, Protozoan
Type of study:
Controlled clinical trial
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2014
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Rio de Janeiro/BR
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