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Interferon-γ inhibits group B Streptococcus survival within human endothelial cells
Lione, Viviane de Oliveira Freitas; Santos, Michelle Hanthequeste Bittencourt dos; Oliveira, Jessica Silva Santos de; Mattos-Guaraldi, Ana Luiza; Nagao, Prescilla Emy.
Affiliation
  • Lione, Viviane de Oliveira Freitas; Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Laboratório de Bioensaios Farmacêuticos. Rio de Janeiro. BR
  • Santos, Michelle Hanthequeste Bittencourt dos; Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Laboratório de Bioensaios Farmacêuticos. Rio de Janeiro. BR
  • Oliveira, Jessica Silva Santos de; Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Laboratório de Bioensaios Farmacêuticos. Rio de Janeiro. BR
  • Mattos-Guaraldi, Ana Luiza; Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Laboratório de Bioensaios Farmacêuticos. Rio de Janeiro. BR
  • Nagao, Prescilla Emy; Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Laboratório de Bioensaios Farmacêuticos. Rio de Janeiro. BR
Mem. Inst. Oswaldo Cruz ; 109(7): 940-943, 11/2014. graf
Article in En | LILACS | ID: lil-728811
Responsible library: BR1.1
ABSTRACT
Endothelial dysfunction is a major component of the pathophysiology of septicaemic group B Streptococcus (GBS) infections. Although cytokines have been shown to activate human umbilical vein endothelial cells (HUVECs), the capacity of interferon (IFN)-γ to enhance the microbicidal activity of HUVECs against GBS has not been studied. We report that the viability of intracellular bacteria was reduced in HUVECs activated by IFN-γ. Enhanced fusion of lysosomes with bacteria-containing vacuoles was observed by acid phosphatase and the colocalisation of Rab-5, Rab-7 and lysosomal-associated membrane protein-1 with GBS in IFN-γ-activated HUVECs. IFN-γ resulted in an enhancement of the phagosome maturation process in HUVECs, improving the capacity to control the intracellular survival of GBS.
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Full text: 1 Index: LILACS Main subject: Streptococcal Infections / Streptococcus agalactiae / Interferon-gamma / Microbial Viability / Human Umbilical Vein Endothelial Cells / Anti-Infective Agents Limits: Humans Language: En Journal: Mem. Inst. Oswaldo Cruz Journal subject: MEDICINA TROPICAL / PARASITOLOGIA Year: 2014 Type: Article

Full text: 1 Index: LILACS Main subject: Streptococcal Infections / Streptococcus agalactiae / Interferon-gamma / Microbial Viability / Human Umbilical Vein Endothelial Cells / Anti-Infective Agents Limits: Humans Language: En Journal: Mem. Inst. Oswaldo Cruz Journal subject: MEDICINA TROPICAL / PARASITOLOGIA Year: 2014 Type: Article